The dynamic biliary epithelia: Molecules, pathways, and disease

Steven P. O'Hara, James H. Tabibian, Patrick L. Splinter, Nicholas F. Larusso

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Cholangiocytes, the cells lining bile ducts, are a heterogenous, highly dynamic population of epithelial cells. While these cells comprise a small fraction of the total cellular component of the liver, they perform the essential role of bile modification and transport of biliary and blood constituents. From a pathophysiological standpoint, cholangiocytes are the target of a diverse group of biliary disorders, collectively referred to as the cholangiopathies. To date, the cause of most cholangiopathies remains obscure. It is known, however, that cholangiocytes exist in an environment rich in potential mediators of cellular injury, express receptors that recognize potential injurious insults, and participate in portal tract repair processes following hepatic injury. As such, cholangiocytes may not be only a passive target, but are likely directly and actively involved in the pathogenesis of cholangiopathies. Here, we briefly summarize the characteristics of the reactive cholangiocyte and cholangiocyte responses to potentially injurious endogenous and exogenous molecules, and in addition, present emerging concepts in our understanding of the etiopathogenesis of several cholangiopathies.

Original languageEnglish (US)
Pages (from-to)575-582
Number of pages8
JournalJournal of Hepatology
Volume58
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • Biliary
  • Cholangiocytes
  • Cholangiopathy
  • Reactivity
  • Repair

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'The dynamic biliary epithelia: Molecules, pathways, and disease'. Together they form a unique fingerprint.

  • Cite this

    O'Hara, S. P., Tabibian, J. H., Splinter, P. L., & Larusso, N. F. (2013). The dynamic biliary epithelia: Molecules, pathways, and disease. Journal of Hepatology, 58(3), 575-582. https://doi.org/10.1016/j.jhep.2012.10.011