The dusky-footed woodrat (neotoma fuscipes) is susceptible to infection by anaplasma phagocytophilum originating from woodrats, horses, and dogs

Nathan C. Nieto, John E Madigan, Janet E Foley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The dusky-footed woodrat (Neotomafuscipes) is the putative reservoir for Anaplasma phagocytophilum in the western United States based on high prevalence of A. phagocytophilum genetic material detected by polymerase chain reaction (PCR), high antibody prevalence, and infestation with the vector tick Ixodes pacifiais. Following inoculation of nine wild-caught woodrats with woodrat-, canine-, or equine-origin A. phagocytophilum, all became PCR-positive and seroconverted. However, when PCR-positive woodrat blood was delivered as inoculum to three horses, the horses never became clinically ill, PCR-positive, or antibody-positive. Each horse was subsequently infected with either the equine- or chipmunk-origin A. phagocytophilum, resulting in clinical anaplasmosis. Our data show that woodrats are permissive to several strains of A. phagocytophilum, but strains originating from woodrats did not cause clinical disease in horses.

Original languageEnglish (US)
Pages (from-to)810-817
Number of pages8
JournalJournal of Wildlife Diseases
Volume46
Issue number3
StatePublished - Jul 2010

Fingerprint

Neotoma
Anaplasma phagocytophilum
biological resistance
horse
polymerase chain reaction
horses
dogs
antibody
tick
Tamias
anaplasmosis
Ixodes
horse diseases
inoculation
Western United States
seroprevalence
blood
ticks
inoculum
dog

Keywords

  • Dusky-footed woodrat
  • Granulocytic anaplasmosis
  • Host-tropism
  • Ixodes pacifiais
  • Neotoma fuscipes
  • Sylvatic reservoir
  • Tick-borne disease

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

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title = "The dusky-footed woodrat (neotoma fuscipes) is susceptible to infection by anaplasma phagocytophilum originating from woodrats, horses, and dogs",
abstract = "The dusky-footed woodrat (Neotomafuscipes) is the putative reservoir for Anaplasma phagocytophilum in the western United States based on high prevalence of A. phagocytophilum genetic material detected by polymerase chain reaction (PCR), high antibody prevalence, and infestation with the vector tick Ixodes pacifiais. Following inoculation of nine wild-caught woodrats with woodrat-, canine-, or equine-origin A. phagocytophilum, all became PCR-positive and seroconverted. However, when PCR-positive woodrat blood was delivered as inoculum to three horses, the horses never became clinically ill, PCR-positive, or antibody-positive. Each horse was subsequently infected with either the equine- or chipmunk-origin A. phagocytophilum, resulting in clinical anaplasmosis. Our data show that woodrats are permissive to several strains of A. phagocytophilum, but strains originating from woodrats did not cause clinical disease in horses.",
keywords = "Dusky-footed woodrat, Granulocytic anaplasmosis, Host-tropism, Ixodes pacifiais, Neotoma fuscipes, Sylvatic reservoir, Tick-borne disease",
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year = "2010",
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AU - Madigan, John E

AU - Foley, Janet E

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N2 - The dusky-footed woodrat (Neotomafuscipes) is the putative reservoir for Anaplasma phagocytophilum in the western United States based on high prevalence of A. phagocytophilum genetic material detected by polymerase chain reaction (PCR), high antibody prevalence, and infestation with the vector tick Ixodes pacifiais. Following inoculation of nine wild-caught woodrats with woodrat-, canine-, or equine-origin A. phagocytophilum, all became PCR-positive and seroconverted. However, when PCR-positive woodrat blood was delivered as inoculum to three horses, the horses never became clinically ill, PCR-positive, or antibody-positive. Each horse was subsequently infected with either the equine- or chipmunk-origin A. phagocytophilum, resulting in clinical anaplasmosis. Our data show that woodrats are permissive to several strains of A. phagocytophilum, but strains originating from woodrats did not cause clinical disease in horses.

AB - The dusky-footed woodrat (Neotomafuscipes) is the putative reservoir for Anaplasma phagocytophilum in the western United States based on high prevalence of A. phagocytophilum genetic material detected by polymerase chain reaction (PCR), high antibody prevalence, and infestation with the vector tick Ixodes pacifiais. Following inoculation of nine wild-caught woodrats with woodrat-, canine-, or equine-origin A. phagocytophilum, all became PCR-positive and seroconverted. However, when PCR-positive woodrat blood was delivered as inoculum to three horses, the horses never became clinically ill, PCR-positive, or antibody-positive. Each horse was subsequently infected with either the equine- or chipmunk-origin A. phagocytophilum, resulting in clinical anaplasmosis. Our data show that woodrats are permissive to several strains of A. phagocytophilum, but strains originating from woodrats did not cause clinical disease in horses.

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