The double life of a B-1 cell: Self-reactivity selects for protective effector functions

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Abstract

During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.

Original languageEnglish (US)
Pages (from-to)34-46
Number of pages13
JournalNature Reviews Immunology
Volume11
Issue number1
DOIs
StatePublished - Jan 2011

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ASJC Scopus subject areas

  • Immunology

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