The dorsal raphe nucleus: A re-evaluation of its proposed role in opiate analgesia systems

D. S. Klatt, M. J. Guinan, E. S. Culhane, Earl Carstens, L. R. Watkins

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Previous studies have concluded that (a) electrical stimulation in the periaqueductal gray/dorsal raphe nucleus (PAG/DRN) region specifically produces either non-opiate or opiate forms of antinociception dependent upon the dorsoventral level of stimulation and (b) the 'opiate' form of stimulation-produced analgesia (SPA) arising from the ventral PAG/DRN region shows cross-tolerance with opiate forms of footshock analgesia, implying common neural substrates. This latter conclusion in turn implies that SPA elicited from the ventral PAG/DRN region would be expected to be antagonized by scopolamine, since this muscarinic cholinergic antagonist blocks opiate footshock analgesia. The present study demonstrates instead that neither 10 mg/kg naloxone nor 10 mg/kg scopolamine had any effect on SPA elicited from sites histologically verified to lie within the presumptive 'opiate' ventral PAG/DRN region. These data bring into question both the site specificity of opiate SPA and the common mediation of ventral PAG/DRN SPA and opiate forms of footshock analgesia.

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalBrain Research
Volume447
Issue number2
DOIs
StatePublished - May 3 1988

Fingerprint

Opiate Alkaloids
Analgesia
Periaqueductal Gray
Scopolamine Hydrobromide
Muscarinic Antagonists
Dorsal Raphe Nucleus
Naloxone
Electric Stimulation

Keywords

  • Acetylcholine
  • Analgesia
  • Behavior
  • Dorsal raphe nucleus
  • Opiate
  • Pain
  • Periaqueductal gray
  • Stimulation produced analgesia

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Klatt, D. S., Guinan, M. J., Culhane, E. S., Carstens, E., & Watkins, L. R. (1988). The dorsal raphe nucleus: A re-evaluation of its proposed role in opiate analgesia systems. Brain Research, 447(2), 246-252. https://doi.org/10.1016/0006-8993(88)91126-2

The dorsal raphe nucleus : A re-evaluation of its proposed role in opiate analgesia systems. / Klatt, D. S.; Guinan, M. J.; Culhane, E. S.; Carstens, Earl; Watkins, L. R.

In: Brain Research, Vol. 447, No. 2, 03.05.1988, p. 246-252.

Research output: Contribution to journalArticle

Klatt, DS, Guinan, MJ, Culhane, ES, Carstens, E & Watkins, LR 1988, 'The dorsal raphe nucleus: A re-evaluation of its proposed role in opiate analgesia systems', Brain Research, vol. 447, no. 2, pp. 246-252. https://doi.org/10.1016/0006-8993(88)91126-2
Klatt, D. S. ; Guinan, M. J. ; Culhane, E. S. ; Carstens, Earl ; Watkins, L. R. / The dorsal raphe nucleus : A re-evaluation of its proposed role in opiate analgesia systems. In: Brain Research. 1988 ; Vol. 447, No. 2. pp. 246-252.
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