The DNA sequence and analysis of human chromosome 14

Roland Heilig, Ralph Eckenberg, Jean Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique De Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François ArtiguenaveCatherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jalllon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anlère, Sylvie Samain, Hervé Crespeau, Nissa Abbasl, Nathalie Aiach, Didler Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthla Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Malrey-Estrada, Sophie Mangenot, Nathalle Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadla Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol-Mavel, Magall Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emille Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalle Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelals, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderie, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, La Deana Hillier, Lucinda Fulton, John Douglas Mcpherson, Fumihiko Matsuda, Rlchard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, Willlam Saurin, Francis Quétler, Robert Waterston, Leroy Hood, Jean Weissenbach

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
JournalNature
Volume421
Issue number6923
DOIs
StatePublished - Feb 6 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • General

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    Heilig, R., Eckenberg, R., Petit, J. L., Fonknechten, N., Da Silva, C., Cattolico, L., Levy, M., Barbe, V., De Berardinis, V., Ureta-Vidal, A., Pelletier, E., Vico, V., Anthouard, V., Rowen, L., Madan, A., Qin, S., Sun, H., Du, H., Pepin, K., ... Weissenbach, J. (2003). The DNA sequence and analysis of human chromosome 14. Nature, 421(6923), 601-607. https://doi.org/10.1038/nature01348