The Division of Endosymbiotic Organelles

Katherine W. Osteryoung, Jodi Nunnari

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Mitochondria and chloroplasts are essential eukaryotic organelles of endosymbiotic origin. Dynamic cellular machineries divide these organelles. The mechanisms by which mitochondria and chloroplasts divide were thought to be fundamentally different because chloroplasts use proteins derived from the ancestral prokaryotic cell division machinery, whereas mitochondria have largely evolved a division apparatus that lacks bacterial cell division components. Recent findings indicate, however, that both types of organelles universally require dynamin-related guanosine triphosphatases to divide. This mechanistic link provides fundamental insights into the molecular events driving the division, and possibly the evolution, of organelles in eukaryotes.

Original languageEnglish (US)
Pages (from-to)1698-1704
Number of pages7
JournalScience
Volume302
Issue number5651
DOIs
StatePublished - Dec 6 2003

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Organelles
Mitochondria
Chloroplasts
Cell Division
Prokaryotic Cells
Chloroplast Proteins
Dynamins
Guanosine
Cellular Structures
Eukaryota

ASJC Scopus subject areas

  • General

Cite this

Osteryoung, K. W., & Nunnari, J. (2003). The Division of Endosymbiotic Organelles. Science, 302(5651), 1698-1704. https://doi.org/10.1126/science.1082192

The Division of Endosymbiotic Organelles. / Osteryoung, Katherine W.; Nunnari, Jodi.

In: Science, Vol. 302, No. 5651, 06.12.2003, p. 1698-1704.

Research output: Contribution to journalArticle

Osteryoung, KW & Nunnari, J 2003, 'The Division of Endosymbiotic Organelles', Science, vol. 302, no. 5651, pp. 1698-1704. https://doi.org/10.1126/science.1082192
Osteryoung KW, Nunnari J. The Division of Endosymbiotic Organelles. Science. 2003 Dec 6;302(5651):1698-1704. https://doi.org/10.1126/science.1082192
Osteryoung, Katherine W. ; Nunnari, Jodi. / The Division of Endosymbiotic Organelles. In: Science. 2003 ; Vol. 302, No. 5651. pp. 1698-1704.
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