Abstract
Mitochondria and chloroplasts are essential eukaryotic organelles of endosymbiotic origin. Dynamic cellular machineries divide these organelles. The mechanisms by which mitochondria and chloroplasts divide were thought to be fundamentally different because chloroplasts use proteins derived from the ancestral prokaryotic cell division machinery, whereas mitochondria have largely evolved a division apparatus that lacks bacterial cell division components. Recent findings indicate, however, that both types of organelles universally require dynamin-related guanosine triphosphatases to divide. This mechanistic link provides fundamental insights into the molecular events driving the division, and possibly the evolution, of organelles in eukaryotes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1698-1704 |
| Number of pages | 7 |
| Journal | Science |
| Volume | 302 |
| Issue number | 5651 |
| DOIs | |
| State | Published - Dec 6 2003 |
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- General
Cite this
The Division of Endosymbiotic Organelles. / Osteryoung, Katherine W.; Nunnari, Jodi.
In: Science, Vol. 302, No. 5651, 06.12.2003, p. 1698-1704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Division of Endosymbiotic Organelles
AU - Osteryoung, Katherine W.
AU - Nunnari, Jodi
PY - 2003/12/6
Y1 - 2003/12/6
N2 - Mitochondria and chloroplasts are essential eukaryotic organelles of endosymbiotic origin. Dynamic cellular machineries divide these organelles. The mechanisms by which mitochondria and chloroplasts divide were thought to be fundamentally different because chloroplasts use proteins derived from the ancestral prokaryotic cell division machinery, whereas mitochondria have largely evolved a division apparatus that lacks bacterial cell division components. Recent findings indicate, however, that both types of organelles universally require dynamin-related guanosine triphosphatases to divide. This mechanistic link provides fundamental insights into the molecular events driving the division, and possibly the evolution, of organelles in eukaryotes.
AB - Mitochondria and chloroplasts are essential eukaryotic organelles of endosymbiotic origin. Dynamic cellular machineries divide these organelles. The mechanisms by which mitochondria and chloroplasts divide were thought to be fundamentally different because chloroplasts use proteins derived from the ancestral prokaryotic cell division machinery, whereas mitochondria have largely evolved a division apparatus that lacks bacterial cell division components. Recent findings indicate, however, that both types of organelles universally require dynamin-related guanosine triphosphatases to divide. This mechanistic link provides fundamental insights into the molecular events driving the division, and possibly the evolution, of organelles in eukaryotes.
UR - http://www.scopus.com/inward/record.url?scp=0345600249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345600249&partnerID=8YFLogxK
U2 - 10.1126/science.1082192
DO - 10.1126/science.1082192
M3 - Article
C2 - 14657485
AN - SCOPUS:0345600249
VL - 302
SP - 1698
EP - 1704
JO - Science
JF - Science
SN - 0036-8075
IS - 5651
ER -