The distribution of tenascin-R in the developing avian nervous system

Laura B. Derr, Laura A. Mckae, Richard P Tucker

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Tenascin-R is an extracellular matrix glycoprotein found in the developing central nervous system. In vitro, tenascin-R promotes axon growth. In order to learn more about the function and regulation of tenascin-R in neural development, we have used monoclonal antibodies to localize tenascin-R immunoreactivity in the developing and adult chicken brain. The earliest stage strained with anti-tenascin-R was embryonic day 6.5, when the matrix surrounding the cell bodies of spinal cord motoneurons was stained. At embryonic day 18, specific brain regions were stained, including the basal nuclei, habenular nuclei, layer 'i' of the optic tectum, and the motor nuclei of cranial nerves. Anti-tenascin-R staining persisted in these regions in the adult chicken brain. Thus, the distribution of tenascin-R immunoreactivity in the developing and mature avian brain is correlated with the distribution of nerve growth factor (NGF)-sensitive neurons, but it is not correlated with neurite outgrowth. Finally, NGF was shown to upregulate tenascin-R expression in PC12 cells, indicating that expression of neuron-derived tenascin-R may be regulated by exogenous.

Original languageEnglish (US)
Pages (from-to)152-164
Number of pages13
JournalJournal of Experimental Zoology
Volume280
Issue number2
StatePublished - Feb 1 1998

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nervous system
Nervous System
brain
nerve growth factor
neurons
chickens
matrix
neurites
neurodevelopment
motor neurons
optics
extracellular matrix
Brain
axons
spinal cord
Nerve Growth Factor
antibody
central nervous system
glycoproteins
monoclonal antibodies

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

The distribution of tenascin-R in the developing avian nervous system. / Derr, Laura B.; Mckae, Laura A.; Tucker, Richard P.

In: Journal of Experimental Zoology, Vol. 280, No. 2, 01.02.1998, p. 152-164.

Research output: Contribution to journalArticle

Derr, Laura B. ; Mckae, Laura A. ; Tucker, Richard P. / The distribution of tenascin-R in the developing avian nervous system. In: Journal of Experimental Zoology. 1998 ; Vol. 280, No. 2. pp. 152-164.
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