The distribution of insecticide resistance in Anopheles gambiae s.l. populations from Cameroon: an update

Hamadou N M Ndjemaï, Salomon Patchoké, Jean Atangana, Josiane Etang, Fréderic Simard, Charles F Bilong Bilong, Lisa Reimer, Anthony Cornel, Gregory C Lanzaro, Etienne Fondjo

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Insecticides are a key component of vector-based malaria control programmes in Cameroon. As part of ongoing resistance surveillance efforts, Anopheles gambiae s.l. female mosquitoes were exposed to organochlorine (DDT), a carbamate (bendiocarb), an organophosphate (malathion), and three pyrethroids (deltamethrin, lambda-cyhalothrin and permethrin) in WHO bioassay test kits. Results indicated a higher level of resistance (reduced mortality and knockdown effect) to DDT and pyrethroids in populations of A. gambiae s.s. than in A. arabiensis. The West and East African knockdown resistance (kdr) mutations were found in both species but at much higher frequencies in A. gambiae s.s. The West Africa kdr mutant was also more frequent in the A. gambiae S form than in the M form. No resistance to bendiocarb and malathion was found. Carbamate and organophosphorous compounds could thus be used as alternatives in locations in Cameroon where pyrethroid-resistant populations are found.

Original languageEnglish (US)
Pages (from-to)1127-1138
Number of pages12
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume103
Issue number11
DOIs
StatePublished - Nov 2009

Keywords

  • Anopheles gambiae s.l.
  • Cameroon
  • Insecticides
  • kdr
  • Malaria
  • Resistance

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

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    Ndjemaï, H. N. M., Patchoké, S., Atangana, J., Etang, J., Simard, F., Bilong, C. F. B., Reimer, L., Cornel, A., Lanzaro, G. C., & Fondjo, E. (2009). The distribution of insecticide resistance in Anopheles gambiae s.l. populations from Cameroon: an update. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(11), 1127-1138. https://doi.org/10.1016/j.trstmh.2008.11.018