The disparate origins of ovarian cancers: Pathogenesis and prevention strategies

Anthony Karnezis; Kathleen R. Cho; C. Blake Gilks; Celeste Leigh Pearce; David G. Huntsman

doi:10.1038/nrc.2016.113

The disparate origins of ovarian cancers: Pathogenesis and prevention strategies

Anthony Karnezis, Kathleen R. Cho, C. Blake Gilks, Celeste Leigh Pearce, David G. Huntsman

Research output: Contribution to journal › Review article

79 Scopus citations

Abstract

Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

Original language	English (US)
Pages (from-to)	65-74
Number of pages	10
Journal	Nature Reviews Cancer
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/nrc.2016.113
State	Published - Jan 1 2017
Externally published	Yes

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ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Karnezis, A., Cho, K. R., Gilks, C. B., Pearce, C. L., & Huntsman, D. G. (2017). The disparate origins of ovarian cancers: Pathogenesis and prevention strategies. Nature Reviews Cancer, 17(1), 65-74. https://doi.org/10.1038/nrc.2016.113

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10.1038/nrc.2016.113