The disparate origins of ovarian cancers: Pathogenesis and prevention strategies

Anthony Karnezis, Kathleen R. Cho, C. Blake Gilks, Celeste Leigh Pearce, David G. Huntsman

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalNature Reviews Cancer
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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