Abstract
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-74 |
| Number of pages | 10 |
| Journal | Nature Reviews Cancer |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
The disparate origins of ovarian cancers : Pathogenesis and prevention strategies. / Karnezis, Anthony; Cho, Kathleen R.; Gilks, C. Blake; Pearce, Celeste Leigh; Huntsman, David G.
In: Nature Reviews Cancer, Vol. 17, No. 1, 01.01.2017, p. 65-74.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The disparate origins of ovarian cancers
T2 - Pathogenesis and prevention strategies
AU - Karnezis, Anthony
AU - Cho, Kathleen R.
AU - Gilks, C. Blake
AU - Pearce, Celeste Leigh
AU - Huntsman, David G.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
AB - Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
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UR - http://www.scopus.com/inward/citedby.url?scp=84996968539&partnerID=8YFLogxK
U2 - 10.1038/nrc.2016.113
DO - 10.1038/nrc.2016.113
M3 - Review article
C2 - 27885265
AN - SCOPUS:84996968539
VL - 17
SP - 65
EP - 74
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 1
ER -