The disparate origins of ovarian cancers: Pathogenesis and prevention strategies

Anthony Karnezis; Kathleen R. Cho; C. Blake Gilks; Celeste Leigh Pearce; David G. Huntsman

doi:10.1038/nrc.2016.113

The disparate origins of ovarian cancers: Pathogenesis and prevention strategies

Anthony Karnezis, Kathleen R. Cho, C. Blake Gilks, Celeste Leigh Pearce, David G. Huntsman

Research output: Contribution to journal › Review article

90 Scopus citations

Abstract

Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

Original language	English (US)
Pages (from-to)	65-74
Number of pages	10
Journal	Nature Reviews Cancer
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/nrc.2016.113
State	Published - Jan 1 2017
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/nrc.2016.113

Fingerprint Dive into the research topics of 'The disparate origins of ovarian cancers: Pathogenesis and prevention strategies'. Together they form a unique fingerprint.

Cite this

Karnezis, A., Cho, K. R., Gilks, C. B., Pearce, C. L., & Huntsman, D. G. (2017). The disparate origins of ovarian cancers: Pathogenesis and prevention strategies. Nature Reviews Cancer, 17(1), 65-74. https://doi.org/10.1038/nrc.2016.113

@article{51434eeeace44db58bf74e2210dbf93d,

title = "The disparate origins of ovarian cancers: Pathogenesis and prevention strategies",

abstract = "Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.",

author = "Anthony Karnezis and Cho, {Kathleen R.} and Gilks, {C. Blake} and Pearce, {Celeste Leigh} and Huntsman, {David G.}",

year = "2017",

month = jan,

day = "1",

doi = "10.1038/nrc.2016.113",

language = "English (US)",

volume = "17",

pages = "65--74",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - The disparate origins of ovarian cancers

T2 - Pathogenesis and prevention strategies

AU - Karnezis, Anthony

AU - Cho, Kathleen R.

AU - Gilks, C. Blake

AU - Pearce, Celeste Leigh

AU - Huntsman, David G.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

AB - Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

UR - http://www.scopus.com/inward/record.url?scp=84996968539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996968539&partnerID=8YFLogxK

U2 - 10.1038/nrc.2016.113

DO - 10.1038/nrc.2016.113

M3 - Review article

C2 - 27885265

AN - SCOPUS:84996968539

VL - 17

SP - 65

EP - 74

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 1

ER -