The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Tracey Goldstein, Simon J. Anthony, Aiah Gbakima, Brian H. Bird, James Bangura, Alexandre Tremeau-Bravard, Manjunatha N. Belaganahalli, Heather L. Wells, Jasjeet K. Dhanota, Eliza Liang, Michael Grodus, Rohit K. Jangra, Veronica A. DeJesus, Gorka Lasso, Brett R. Smith, Amara Jambai, Brima O. Kamara, Sorie Kamara, William Bangura, Corina MonaginSagi Shapira, Christine K Johnson, Karen Saylors, Edward M. Rubin, Kartik Chandran, W. Ian Lipkin, Jonna A Mazet

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

Original languageEnglish (US)
Pages (from-to)1084-1089
Number of pages6
JournalNature Microbiology
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Ebolavirus
Viruses
Sierra Leone
Glycoproteins
Genome

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

Cite this

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. / Goldstein, Tracey; Anthony, Simon J.; Gbakima, Aiah; Bird, Brian H.; Bangura, James; Tremeau-Bravard, Alexandre; Belaganahalli, Manjunatha N.; Wells, Heather L.; Dhanota, Jasjeet K.; Liang, Eliza; Grodus, Michael; Jangra, Rohit K.; DeJesus, Veronica A.; Lasso, Gorka; Smith, Brett R.; Jambai, Amara; Kamara, Brima O.; Kamara, Sorie; Bangura, William; Monagin, Corina; Shapira, Sagi; Johnson, Christine K; Saylors, Karen; Rubin, Edward M.; Chandran, Kartik; Lipkin, W. Ian; Mazet, Jonna A.

In: Nature Microbiology, Vol. 3, No. 10, 01.10.2018, p. 1084-1089.

Research output: Contribution to journalArticle

Goldstein, T, Anthony, SJ, Gbakima, A, Bird, BH, Bangura, J, Tremeau-Bravard, A, Belaganahalli, MN, Wells, HL, Dhanota, JK, Liang, E, Grodus, M, Jangra, RK, DeJesus, VA, Lasso, G, Smith, BR, Jambai, A, Kamara, BO, Kamara, S, Bangura, W, Monagin, C, Shapira, S, Johnson, CK, Saylors, K, Rubin, EM, Chandran, K, Lipkin, WI & Mazet, JA 2018, 'The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses', Nature Microbiology, vol. 3, no. 10, pp. 1084-1089. https://doi.org/10.1038/s41564-018-0227-2
Goldstein, Tracey ; Anthony, Simon J. ; Gbakima, Aiah ; Bird, Brian H. ; Bangura, James ; Tremeau-Bravard, Alexandre ; Belaganahalli, Manjunatha N. ; Wells, Heather L. ; Dhanota, Jasjeet K. ; Liang, Eliza ; Grodus, Michael ; Jangra, Rohit K. ; DeJesus, Veronica A. ; Lasso, Gorka ; Smith, Brett R. ; Jambai, Amara ; Kamara, Brima O. ; Kamara, Sorie ; Bangura, William ; Monagin, Corina ; Shapira, Sagi ; Johnson, Christine K ; Saylors, Karen ; Rubin, Edward M. ; Chandran, Kartik ; Lipkin, W. Ian ; Mazet, Jonna A. / The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. In: Nature Microbiology. 2018 ; Vol. 3, No. 10. pp. 1084-1089.
@article{94fa1f04686347d3bcaff7de8d16bd28,
title = "The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses",
abstract = "Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.",
author = "Tracey Goldstein and Anthony, {Simon J.} and Aiah Gbakima and Bird, {Brian H.} and James Bangura and Alexandre Tremeau-Bravard and Belaganahalli, {Manjunatha N.} and Wells, {Heather L.} and Dhanota, {Jasjeet K.} and Eliza Liang and Michael Grodus and Jangra, {Rohit K.} and DeJesus, {Veronica A.} and Gorka Lasso and Smith, {Brett R.} and Amara Jambai and Kamara, {Brima O.} and Sorie Kamara and William Bangura and Corina Monagin and Sagi Shapira and Johnson, {Christine K} and Karen Saylors and Rubin, {Edward M.} and Kartik Chandran and Lipkin, {W. Ian} and Mazet, {Jonna A}",
year = "2018",
month = "10",
day = "1",
doi = "10.1038/s41564-018-0227-2",
language = "English (US)",
volume = "3",
pages = "1084--1089",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

AU - Goldstein, Tracey

AU - Anthony, Simon J.

AU - Gbakima, Aiah

AU - Bird, Brian H.

AU - Bangura, James

AU - Tremeau-Bravard, Alexandre

AU - Belaganahalli, Manjunatha N.

AU - Wells, Heather L.

AU - Dhanota, Jasjeet K.

AU - Liang, Eliza

AU - Grodus, Michael

AU - Jangra, Rohit K.

AU - DeJesus, Veronica A.

AU - Lasso, Gorka

AU - Smith, Brett R.

AU - Jambai, Amara

AU - Kamara, Brima O.

AU - Kamara, Sorie

AU - Bangura, William

AU - Monagin, Corina

AU - Shapira, Sagi

AU - Johnson, Christine K

AU - Saylors, Karen

AU - Rubin, Edward M.

AU - Chandran, Kartik

AU - Lipkin, W. Ian

AU - Mazet, Jonna A

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

AB - Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

UR - http://www.scopus.com/inward/record.url?scp=85052954021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052954021&partnerID=8YFLogxK

U2 - 10.1038/s41564-018-0227-2

DO - 10.1038/s41564-018-0227-2

M3 - Article

C2 - 30150734

AN - SCOPUS:85052954021

VL - 3

SP - 1084

EP - 1089

JO - Nature Microbiology

JF - Nature Microbiology

SN - 2058-5276

IS - 10

ER -