The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Tracey Goldstein, Simon J. Anthony, Aiah Gbakima, Brian H. Bird, James Bangura, Alexandre Tremeau-Bravard, Manjunatha N. Belaganahalli, Heather L. Wells, Jasjeet K. Dhanota, Eliza Liang, Michael Grodus, Rohit K. Jangra, Veronica A. DeJesus, Gorka Lasso, Brett R. Smith, Amara Jambai, Brima O. Kamara, Sorie Kamara, William Bangura, Corina MonaginSagi Shapira, Christine K Johnson, Karen Saylors, Edward M. Rubin, Kartik Chandran, W. Ian Lipkin, Jonna A Mazet

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

Original languageEnglish (US)
Pages (from-to)1084-1089
Number of pages6
JournalNature Microbiology
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2018

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

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    Goldstein, T., Anthony, S. J., Gbakima, A., Bird, B. H., Bangura, J., Tremeau-Bravard, A., Belaganahalli, M. N., Wells, H. L., Dhanota, J. K., Liang, E., Grodus, M., Jangra, R. K., DeJesus, V. A., Lasso, G., Smith, B. R., Jambai, A., Kamara, B. O., Kamara, S., Bangura, W., ... Mazet, J. A. (2018). The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. Nature Microbiology, 3(10), 1084-1089. https://doi.org/10.1038/s41564-018-0227-2