The difference δ-cells make in glucose control

Mark O. Huising, Talitha van der Meulen, Jessica L. Huang, Mohammad S. Pourhosseinzadeh, Glyn M. Noguchi

Research output: Contribution to journalReview articlepeer-review

Abstract

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

Original languageEnglish (US)
Pages (from-to)403-411
Number of pages9
JournalPhysiology
Volume33
Issue number6
DOIs
StatePublished - Nov 1 2018

ASJC Scopus subject areas

  • Physiology

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