Abstract
The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.
Original language | English (US) |
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Pages (from-to) | 403-411 |
Number of pages | 9 |
Journal | Physiology |
Volume | 33 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1 2018 |
ASJC Scopus subject areas
- Physiology