The difference δ-cells make in glucose control

Mark O. Huising; Talitha van der Meulen; Jessica L. Huang; Mohammad S. Pourhosseinzadeh; Glyn M. Noguchi

doi:10.1152/physiol.00029.2018

The difference δ-cells make in glucose control

Mark O. Huising, Talitha van der Meulen, Jessica L. Huang, Mohammad S. Pourhosseinzadeh, Glyn M. Noguchi

Physiology and Membrane Biology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

Original language	English (US)
Pages (from-to)	403-411
Number of pages	9
Journal	Physiology
Volume	33
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00029.2018
State	Published - Nov 1 2018

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00029.2018

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AU - Huang, Jessica L.

AU - Pourhosseinzadeh, Mohammad S.

AU - Noguchi, Glyn M.

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N2 - The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

AB - The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

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The difference δ-cells make in glucose control

Abstract

ASJC Scopus subject areas

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