The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin

Alena Dvorakova-Lorenzova, Pavel Suchánek, Peter J Havel, Petr Stávek, Ludmila Karasová, Zdeněk Valenta, Jaroslav Tintěra, Rudolf Poledne

Research output: Contribution to journalArticle

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Abstract

Subclinical inflammation is a risk factor for cardiovascular disease. The mechanisms underlying increased levels of inflammatory markers and their changes in response to weight loss are not fully understood yet. It has been proposed that elevated concentrations of C-reactive protein (CRP) are mediated by cytokines produced in adipose tissue. We investigated the changes in circulating CRP after weight reduction, in relation to parameters relevant to the metabolic syndrome. Forty 25- to 35-year-old obese female volunteers participated in an intervention program of dietary education and supervised physical activity for a period of 9 weeks. Anthropological parameters and biochemical measurements (high-sensitivity CRP [hsCRP], plasma lipoproteins, interleukin 6 [IL-6], adiponectin) were analyzed before and after the intervention. Body mass index decreased by more than 7% from 31.5 ± 4.1 to 29.1 ± 3.9. Plasma free fatty acid (FFA) concentrations decreased by 30%, high-density lipoprotein cholesterol increased by 8%, and fasting insulin concentrations decreased by 15%. There were no significant changes in either low-density lipoprotein cholesterol or triacylglycerol concentrations. Subcutaneous and visceral adipose tissue mass decreased by 12% and 18%. High-sensitivity CRP concentrations decreased by 30%; however, mean plasma IL-6 and adiponectin concentrations remained unchanged. In linear regression analysis, the changes in plasma hsCRP concentrations were associated with baseline hsCRP concentration, change in triacylglycerols and FFA concentrations, and in waist circumference. The decrease in hsCRP concentration after weight reduction does not appear to be mediated by decreases in circulating IL-6 or adiponectin concentrations; however, change in hsCRP concentration is related to changes in waist circumference and lipid metabolism, reflected by plasma triacylglycerol and FFA levels.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume55
Issue number3
DOIs
StatePublished - Mar 2006

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Adiponectin
C-Reactive Protein
Weight Loss
Interleukin-6
Exercise
Diet
Lipids
Nonesterified Fatty Acids
Triglycerides
Waist Circumference
Anthropology
Intra-Abdominal Fat
Subcutaneous Fat
Lipid Metabolism
LDL Cholesterol
HDL Cholesterol
Lipoproteins
Adipose Tissue
Volunteers
Linear Models

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin. / Dvorakova-Lorenzova, Alena; Suchánek, Pavel; Havel, Peter J; Stávek, Petr; Karasová, Ludmila; Valenta, Zdeněk; Tintěra, Jaroslav; Poledne, Rudolf.

In: Metabolism: Clinical and Experimental, Vol. 55, No. 3, 03.2006, p. 359-365.

Research output: Contribution to journalArticle

Dvorakova-Lorenzova, Alena ; Suchánek, Pavel ; Havel, Peter J ; Stávek, Petr ; Karasová, Ludmila ; Valenta, Zdeněk ; Tintěra, Jaroslav ; Poledne, Rudolf. / The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin. In: Metabolism: Clinical and Experimental. 2006 ; Vol. 55, No. 3. pp. 359-365.
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AU - Valenta, Zdeněk

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