The cutaneous and intestinal microbiome in psoriatic disease

Stephanie T. Le, Atrin Toussi, Natalia Maverakis, Alina I. Marusina, Virgina R. Barton, Alexander A. Merleev, Guillaume Luxardi, Siba P. Raychaudhuri, Emanual Michael Maverakis

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated inflammatory diseases of multifactorial etiology. In addition to genetic and environmental factors, evidence supports involvement of a dysregulated human microbiome in the pathogenesis of psoriatic disease. In particular, alterations in the composition of the microbiome, termed dysbiosis, can result in downstream proinflammatory effects in the gut, skin, and joints. Both the cutaneous and intestinal microbial populations are implicated in the pathogenesis of psoriatic disease, although exact mechanisms are unclear. Herein, we review the relationship between the human microbiome and psoriatic disease. Further insight into the functions of the microbiome may allow for greater understanding of inflammatory disease processes and identification of additional therapeutic targets.

Original languageEnglish (US)
Article number108537
JournalClinical Immunology
Volume218
DOIs
StatePublished - Sep 2020

Keywords

  • Autoimmunity
  • Inflammatory bowel disease
  • Microbiome
  • Psoriasis
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Le, S. T., Toussi, A., Maverakis, N., Marusina, A. I., Barton, V. R., Merleev, A. A., Luxardi, G., Raychaudhuri, S. P., & Maverakis, E. M. (2020). The cutaneous and intestinal microbiome in psoriatic disease. Clinical Immunology, 218, [108537]. https://doi.org/10.1016/j.clim.2020.108537