The current state of stem cell therapy for peripheral artery disease

Nitin K. Gupta, Ehrin J. Armstrong, Sahil A. Parikh

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.

Original languageEnglish (US)
JournalCurrent Cardiology Reports
Issue number2
StatePublished - 2014
Externally publishedYes


  • Critical limb ischemia
  • Peripheral artery disease
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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