Abstract
While only a small percentage of the liver as dendritic cells, they play a major role in the regulation of liver immunity. Four major types of dendritic cell subsets include myeloid CD8alpha(-)B220(-), lymphoid CD8alpha(+)B220(-), plasmacytoid CD8alpha(-)B220(+), and natural killer dendritic cell with CD8alpha(-)B220(-)NK1.1(+) phenotype. Although these subsets have slightly different characteristics, they are all poor naïve T cell stimulators. In exchange for their reduced capacity for allostimulation, hepatic DCs are equipped with an enhanced ability to secrete cytokines in response to TLR stimulation. In addition, they have increased level of phagocytosis. Both of these traits suggest hepatic DC as part of the innate immune system. With such a high rate of exposure to the dietary and commensal antigens, it is important for the hepatic DCs to have an enhanced innate response while maintaining a tolerogenic state to avoid chronic inflammation. Only upon secondary infectivity does the hepatic DC activate memory T cells for rapid eradication of recurring pathogen. On the other hand, overly tolerogenic characteristics of hepatic DC may be responsible for the increase prevalence of autoimmunity or liver malignancies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 321-328 |
| Number of pages | 8 |
| Journal | Cellular & molecular immunology |
| Volume | 4 |
| Issue number | 5 |
| State | Published - Oct 2007 |
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- Medicine(all)
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The current immune function of hepatic dendritic cells. / Hsu, Willy; Shu, Shang An; Gershwin, M. Eric; Lian, Zhe Xiong.
In: Cellular & molecular immunology, Vol. 4, No. 5, 10.2007, p. 321-328.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The current immune function of hepatic dendritic cells.
AU - Hsu, Willy
AU - Shu, Shang An
AU - Gershwin, M. Eric
AU - Lian, Zhe Xiong
PY - 2007/10
Y1 - 2007/10
N2 - While only a small percentage of the liver as dendritic cells, they play a major role in the regulation of liver immunity. Four major types of dendritic cell subsets include myeloid CD8alpha(-)B220(-), lymphoid CD8alpha(+)B220(-), plasmacytoid CD8alpha(-)B220(+), and natural killer dendritic cell with CD8alpha(-)B220(-)NK1.1(+) phenotype. Although these subsets have slightly different characteristics, they are all poor naïve T cell stimulators. In exchange for their reduced capacity for allostimulation, hepatic DCs are equipped with an enhanced ability to secrete cytokines in response to TLR stimulation. In addition, they have increased level of phagocytosis. Both of these traits suggest hepatic DC as part of the innate immune system. With such a high rate of exposure to the dietary and commensal antigens, it is important for the hepatic DCs to have an enhanced innate response while maintaining a tolerogenic state to avoid chronic inflammation. Only upon secondary infectivity does the hepatic DC activate memory T cells for rapid eradication of recurring pathogen. On the other hand, overly tolerogenic characteristics of hepatic DC may be responsible for the increase prevalence of autoimmunity or liver malignancies.
AB - While only a small percentage of the liver as dendritic cells, they play a major role in the regulation of liver immunity. Four major types of dendritic cell subsets include myeloid CD8alpha(-)B220(-), lymphoid CD8alpha(+)B220(-), plasmacytoid CD8alpha(-)B220(+), and natural killer dendritic cell with CD8alpha(-)B220(-)NK1.1(+) phenotype. Although these subsets have slightly different characteristics, they are all poor naïve T cell stimulators. In exchange for their reduced capacity for allostimulation, hepatic DCs are equipped with an enhanced ability to secrete cytokines in response to TLR stimulation. In addition, they have increased level of phagocytosis. Both of these traits suggest hepatic DC as part of the innate immune system. With such a high rate of exposure to the dietary and commensal antigens, it is important for the hepatic DCs to have an enhanced innate response while maintaining a tolerogenic state to avoid chronic inflammation. Only upon secondary infectivity does the hepatic DC activate memory T cells for rapid eradication of recurring pathogen. On the other hand, overly tolerogenic characteristics of hepatic DC may be responsible for the increase prevalence of autoimmunity or liver malignancies.
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M3 - Article
C2 - 17976311
AN - SCOPUS:39149132510
VL - 4
SP - 321
EP - 328
JO - Cellular and Molecular Immunology
JF - Cellular and Molecular Immunology
SN - 1672-7681
IS - 5
ER -