The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

Samantha D. Francis Stuart, Nicole M. De Jesus, Merry L. Lindsey, Crystal M Ripplinger

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Optimal healing of damaged tissue following myocardial infarction (MI) requires a coordinated cellular response that can be divided into three phases: inflammatory, proliferative/reparative, and maturation. The inflammatory phase, characterized by rapid influx of cytokines, chemokines, and immune cells, is critical to the removal of damaged tissue. The onset of the proliferative/reparative phase is marked by increased proliferation of myofibroblasts and secretion of collagen to replace dead tissue. Lastly, crosslinking of collagen fibers and apoptosis of immune cells marks the maturation phase. Excessive inflammation or fibrosis has been linked to increased incidence of arrhythmia and other MI-related pathologies. This review describes the roles of inflammation and fibrosis in arrhythmogenesis and prospective therapies for anti-arrhythmic treatment.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume91
DOIs
StatePublished - Feb 1 2016

Fingerprint

Cardiac Arrhythmias
Fibrosis
Myocardial Infarction
Inflammation
Collagen
Myofibroblasts
Anti-Arrhythmia Agents
Chemokines
Apoptosis
Pathology
Cytokines
Incidence
Therapeutics

Keywords

  • Arrhythmia
  • Fibrosis
  • Inflammation
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction. / Francis Stuart, Samantha D.; De Jesus, Nicole M.; Lindsey, Merry L.; Ripplinger, Crystal M.

In: Journal of Molecular and Cellular Cardiology, Vol. 91, 01.02.2016, p. 114-122.

Research output: Contribution to journalReview article

Francis Stuart, Samantha D. ; De Jesus, Nicole M. ; Lindsey, Merry L. ; Ripplinger, Crystal M. / The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction. In: Journal of Molecular and Cellular Cardiology. 2016 ; Vol. 91. pp. 114-122.
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