The Creatine Kinase System in Normal and Diseased Human Myocardium

Joanne S. Ingwall, Martha F. Kramer, Michael A. Fifer, Beverly H. Lorell, Richard Shemin, William Grossman, P. D. Allen

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

We measured creatine kinase activity, isozyme composition, and total creatine content in biopsy samples of left ventricular myocardium from 34 adults in four groups: subjects with normal left ventricles, patients with left ventricular hypertrophy due to aortic stenosis, patients with coronary artery disease without left ventricular hypertrophy, and patients with coronary artery disease and left ventricular hypertrophy due to aortic stenosis. As compared with specimens of normal left ventricles, those from all patients with left ventricular hypertrophy had lower creatine kinase activity, higher MB creatine kinase isozyme content and activity, and lower creatine content. Specimens from the patients without left ventricular hypertrophy had normal creatine kinase activity, increased MB creatine kinase isozyme content and activity, and decreased total creatine content. The normal ventricles showed almost no MB isozyme content or activity. These data suggest that changes in the creatine kinase system occur in both pressure-overload hypertrophy and coronary artery disease. Patients with myocardial infarction who have mild or no preexisting fixed coronary artery disease or pressure-overload hypertrophy would not be expected to have elevation of serum MB creatine kinase. (N Engl J Med 1985; 313:1050–4.).

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalNew England Journal of Medicine
Volume313
Issue number17
DOIs
StatePublished - Oct 24 1985
Externally publishedYes

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Creatine Kinase
Left Ventricular Hypertrophy
Myocardium
MB Form Creatine Kinase
Isoenzymes
Creatine
Coronary Artery Disease
Aortic Valve Stenosis
Hypertrophy
Heart Ventricles
Pressure
Myocardial Infarction
Biopsy
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ingwall, J. S., Kramer, M. F., Fifer, M. A., Lorell, B. H., Shemin, R., Grossman, W., & Allen, P. D. (1985). The Creatine Kinase System in Normal and Diseased Human Myocardium. New England Journal of Medicine, 313(17), 1050-1054. https://doi.org/10.1056/NEJM198510243131704

The Creatine Kinase System in Normal and Diseased Human Myocardium. / Ingwall, Joanne S.; Kramer, Martha F.; Fifer, Michael A.; Lorell, Beverly H.; Shemin, Richard; Grossman, William; Allen, P. D.

In: New England Journal of Medicine, Vol. 313, No. 17, 24.10.1985, p. 1050-1054.

Research output: Contribution to journalArticle

Ingwall, JS, Kramer, MF, Fifer, MA, Lorell, BH, Shemin, R, Grossman, W & Allen, PD 1985, 'The Creatine Kinase System in Normal and Diseased Human Myocardium', New England Journal of Medicine, vol. 313, no. 17, pp. 1050-1054. https://doi.org/10.1056/NEJM198510243131704
Ingwall JS, Kramer MF, Fifer MA, Lorell BH, Shemin R, Grossman W et al. The Creatine Kinase System in Normal and Diseased Human Myocardium. New England Journal of Medicine. 1985 Oct 24;313(17):1050-1054. https://doi.org/10.1056/NEJM198510243131704
Ingwall, Joanne S. ; Kramer, Martha F. ; Fifer, Michael A. ; Lorell, Beverly H. ; Shemin, Richard ; Grossman, William ; Allen, P. D. / The Creatine Kinase System in Normal and Diseased Human Myocardium. In: New England Journal of Medicine. 1985 ; Vol. 313, No. 17. pp. 1050-1054.
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