The Creatine Kinase System in Normal and Diseased Human Myocardium

Joanne S. Ingwall, Martha F. Kramer, Michael A. Fifer, Beverly H. Lorell, Richard Shemin, William Grossman, P. D. Allen

Research output: Contribution to journalArticle

320 Scopus citations

Abstract

We measured creatine kinase activity, isozyme composition, and total creatine content in biopsy samples of left ventricular myocardium from 34 adults in four groups: subjects with normal left ventricles, patients with left ventricular hypertrophy due to aortic stenosis, patients with coronary artery disease without left ventricular hypertrophy, and patients with coronary artery disease and left ventricular hypertrophy due to aortic stenosis. As compared with specimens of normal left ventricles, those from all patients with left ventricular hypertrophy had lower creatine kinase activity, higher MB creatine kinase isozyme content and activity, and lower creatine content. Specimens from the patients without left ventricular hypertrophy had normal creatine kinase activity, increased MB creatine kinase isozyme content and activity, and decreased total creatine content. The normal ventricles showed almost no MB isozyme content or activity. These data suggest that changes in the creatine kinase system occur in both pressure-overload hypertrophy and coronary artery disease. Patients with myocardial infarction who have mild or no preexisting fixed coronary artery disease or pressure-overload hypertrophy would not be expected to have elevation of serum MB creatine kinase. (N Engl J Med 1985; 313:1050–4.).

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalNew England Journal of Medicine
Volume313
Issue number17
DOIs
StatePublished - Oct 24 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Ingwall, J. S., Kramer, M. F., Fifer, M. A., Lorell, B. H., Shemin, R., Grossman, W., & Allen, P. D. (1985). The Creatine Kinase System in Normal and Diseased Human Myocardium. New England Journal of Medicine, 313(17), 1050-1054. https://doi.org/10.1056/NEJM198510243131704