The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21

M. M. Locke; L. S. Ruth; L. V. Millon; Cecilia Penedo; J. D. Murray; A. T. Bowling

doi:10.1046/j.1365-2052.2001.00806.x

The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21

M. M. Locke, L. S. Ruth, L. V. Millon, Cecilia Penedo, J. D. Murray, A. T. Bowling

School of Veterinary Medicine

Research output: Contribution to journal › Article

21 Scopus citations

Abstract

The colour locus historically referred to as C in the horse is linked to microsatellites markers on horse chromosome 21. Preliminary results demonstrated linkage of C^cr, thought to be the cream dilution variant of the C locus, to HTG10. An analysis of horse chromosome 21 using additional families confirmed and established a group of markers linked to C^cr. This work also improved the resolution of previously reported linkage maps for this chromosome. Linkage analysis unambiguously produced the map order: SGCV16-(19.1 cM)-HTG10-(3.8 cM)-LEX60/COR73-(1.3 cM)-COR68-(4.5 cM)-C^cr-(11.9 cM)-LEX31. Comparative and synteny data suggested that the horse C locus is not tyrosinase (TYR).

Original language	English (US)
Pages (from-to)	340-343
Number of pages	4
Journal	Animal Genetics
Volume	32
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2052.2001.00806.x
State	Published - Dec 1 2001

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Keywords

Buckskin
Coat colour
Cream
Dilution
Horse genetics
Microsatellite
Palomino

ASJC Scopus subject areas

Animal Science and Zoology
Genetics

Cite this

Locke, M. M., Ruth, L. S., Millon, L. V., Penedo, C., Murray, J. D., & Bowling, A. T. (2001). The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21. Animal Genetics, 32(6), 340-343. https://doi.org/10.1046/j.1365-2052.2001.00806.x

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title = "The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21",

abstract = "The colour locus historically referred to as C in the horse is linked to microsatellites markers on horse chromosome 21. Preliminary results demonstrated linkage of Ccr, thought to be the cream dilution variant of the C locus, to HTG10. An analysis of horse chromosome 21 using additional families confirmed and established a group of markers linked to Ccr. This work also improved the resolution of previously reported linkage maps for this chromosome. Linkage analysis unambiguously produced the map order: SGCV16-(19.1 cM)-HTG10-(3.8 cM)-LEX60/COR73-(1.3 cM)-COR68-(4.5 cM)-Ccr-(11.9 cM)-LEX31. Comparative and synteny data suggested that the horse C locus is not tyrosinase (TYR).",

keywords = "Buckskin, Coat colour, Cream, Dilution, Horse genetics, Microsatellite, Palomino",

author = "Locke, {M. M.} and Ruth, {L. S.} and Millon, {L. V.} and Cecilia Penedo and Murray, {J. D.} and Bowling, {A. T.}",

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AU - Locke, M. M.

AU - Ruth, L. S.

AU - Millon, L. V.

AU - Penedo, Cecilia

AU - Murray, J. D.

AU - Bowling, A. T.

PY - 2001/12/1

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N2 - The colour locus historically referred to as C in the horse is linked to microsatellites markers on horse chromosome 21. Preliminary results demonstrated linkage of Ccr, thought to be the cream dilution variant of the C locus, to HTG10. An analysis of horse chromosome 21 using additional families confirmed and established a group of markers linked to Ccr. This work also improved the resolution of previously reported linkage maps for this chromosome. Linkage analysis unambiguously produced the map order: SGCV16-(19.1 cM)-HTG10-(3.8 cM)-LEX60/COR73-(1.3 cM)-COR68-(4.5 cM)-Ccr-(11.9 cM)-LEX31. Comparative and synteny data suggested that the horse C locus is not tyrosinase (TYR).

AB - The colour locus historically referred to as C in the horse is linked to microsatellites markers on horse chromosome 21. Preliminary results demonstrated linkage of Ccr, thought to be the cream dilution variant of the C locus, to HTG10. An analysis of horse chromosome 21 using additional families confirmed and established a group of markers linked to Ccr. This work also improved the resolution of previously reported linkage maps for this chromosome. Linkage analysis unambiguously produced the map order: SGCV16-(19.1 cM)-HTG10-(3.8 cM)-LEX60/COR73-(1.3 cM)-COR68-(4.5 cM)-Ccr-(11.9 cM)-LEX31. Comparative and synteny data suggested that the horse C locus is not tyrosinase (TYR).

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KW - Horse genetics

KW - Microsatellite

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10.1046/j.1365-2052.2001.00806.x