The course of neurocognition and social functioning in individuals at ultra high risk for psychosis

Tara A Niendam, Carrie E. Bearden, Jamie Zinberg, Jennifer K. Johnson, Mary O'Brien, Tyrone D. Cannon

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Objective: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. Methods: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. Results: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50% demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. Conclusions: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.

Original languageEnglish (US)
Pages (from-to)772-781
Number of pages10
JournalSchizophrenia Bulletin
Volume33
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Psychotic Disorders
Neurobehavioral Manifestations
Longitudinal Studies

Keywords

  • Cognition
  • Functional outcome
  • High risk
  • Prodrome
  • Psychosis
  • Social functioning

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

The course of neurocognition and social functioning in individuals at ultra high risk for psychosis. / Niendam, Tara A; Bearden, Carrie E.; Zinberg, Jamie; Johnson, Jennifer K.; O'Brien, Mary; Cannon, Tyrone D.

In: Schizophrenia Bulletin, Vol. 33, No. 3, 09.2007, p. 772-781.

Research output: Contribution to journalArticle

Niendam, Tara A ; Bearden, Carrie E. ; Zinberg, Jamie ; Johnson, Jennifer K. ; O'Brien, Mary ; Cannon, Tyrone D. / The course of neurocognition and social functioning in individuals at ultra high risk for psychosis. In: Schizophrenia Bulletin. 2007 ; Vol. 33, No. 3. pp. 772-781.
@article{af018c2397f04099b7e9980401ae2e6a,
title = "The course of neurocognition and social functioning in individuals at ultra high risk for psychosis",
abstract = "Objective: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. Methods: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. Results: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50{\%} demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. Conclusions: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.",
keywords = "Cognition, Functional outcome, High risk, Prodrome, Psychosis, Social functioning",
author = "Niendam, {Tara A} and Bearden, {Carrie E.} and Jamie Zinberg and Johnson, {Jennifer K.} and Mary O'Brien and Cannon, {Tyrone D.}",
year = "2007",
month = "9",
doi = "10.1093/schbul/sbm020",
language = "English (US)",
volume = "33",
pages = "772--781",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - The course of neurocognition and social functioning in individuals at ultra high risk for psychosis

AU - Niendam, Tara A

AU - Bearden, Carrie E.

AU - Zinberg, Jamie

AU - Johnson, Jennifer K.

AU - O'Brien, Mary

AU - Cannon, Tyrone D.

PY - 2007/9

Y1 - 2007/9

N2 - Objective: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. Methods: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. Results: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50% demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. Conclusions: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.

AB - Objective: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. Methods: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. Results: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50% demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. Conclusions: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.

KW - Cognition

KW - Functional outcome

KW - High risk

KW - Prodrome

KW - Psychosis

KW - Social functioning

UR - http://www.scopus.com/inward/record.url?scp=34548038171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548038171&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbm020

DO - 10.1093/schbul/sbm020

M3 - Article

C2 - 17420177

AN - SCOPUS:34548038171

VL - 33

SP - 772

EP - 781

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 3

ER -