The course of neurocognition and social functioning in individuals at ultra high risk for psychosis

Tara A Niendam, Carrie E. Bearden, Jamie Zinberg, Jennifer K. Johnson, Mary O'Brien, Tyrone D. Cannon

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Objective: This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. Methods: Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. Results: UHR subjects showed significant cognitive deficits at baseline and 2 distinct profiles of cognitive change over time. On average, 50% demonstrated improvement in social and role functioning over the follow-up period, while the other half showed either stability or decline in functioning. Functional improvement was associated with improved processing speed and visual memory, as well as improvement in clinical symptoms over the follow-up period. In contrast, patients who did not improve functionally showed stable clinical symptoms and cognitive performance over time. Conclusions: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.

Original languageEnglish (US)
Pages (from-to)772-781
Number of pages10
JournalSchizophrenia Bulletin
Volume33
Issue number3
DOIs
StatePublished - Sep 2007

Keywords

  • Cognition
  • Functional outcome
  • High risk
  • Prodrome
  • Psychosis
  • Social functioning

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

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