The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

David C. Clark, Aaron Brault, Elizabeth Hunsperger

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.

Original languageEnglish (US)
Pages (from-to)1423-1440
Number of pages18
JournalArchives of Virology
Volume157
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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