The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys

Angela Colagross-Schouten, Marie Josee Lemoy, Rebekah I. Keesler, Elaine Lissner, Catherine A. VandeVoort

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. Methods: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history. Results: Treated males have had no conceptions since Vasalgel injections. All males were housed with intact females for at least one breeding season and seven have been almost continually housed with females for 2 years. Complications were minor and included one incident of incorrect placement of Vasalgel into the vas deferens and the development of a sperm granuloma in one animal. Three unilateral vasectomies were performed, one was necessary for incorrect placement of Vasalgel, the other two were elective. Conclusions: Intravas injection of Vasalgel in sexually mature adult male rhesus monkeys was effective in preventing conception in a free-living, group environment. Complications were few and similar to those associated with traditional vasectomy.

Original languageEnglish (US)
Article number4
JournalBasic and Clinical Andrology
Volume27
Issue number1
DOIs
StatePublished - Feb 7 2017

Keywords

  • Colony management
  • Contraception
  • Fertility
  • Hydrogel
  • Macaca mulatta
  • Primate
  • Sterilization
  • Styrene maleic acid polymer
  • Vas deferens
  • Vasalgel
  • Vasectomy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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    Colagross-Schouten, A., Lemoy, M. J., Keesler, R. I., Lissner, E., & VandeVoort, C. A. (2017). The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys. Basic and Clinical Andrology, 27(1), [4]. https://doi.org/10.1186/s12610-017-0048-9