The consequences of apoptosis in autoimmunity

Ana Lleo, Carlo Selmi, Pietro Invernizzi, Mauro Podda, M. Eric Gershwin

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

The clearance of apoptotic cells is a highly regulated mechanism, normally associated with anti-inflammatory response. During early stages of apoptosis the cell is promptly recognized and engulfed by professional phagocytes or tissue cells to avoid the outflow of intracellular content and limit the immunological reaction against released antigens. However, increasing evidences suggest that impairment in the uptake of apoptotic cell debris is linked to the development of autoimmunity. In fact, autoantigens have been demonstrated to be content within apoptotic bodies and apoptotic cells seems to be critical in the presentation of antigens, activation of innate immunity and regulation of macrophage cytokine secretion. We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalJournal of Autoimmunity
Volume31
Issue number3
DOIs
StatePublished - Nov 2008

Keywords

  • Autoantibodies
  • Cell clearance
  • Lupus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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