The complete genome sequence of Haloferax volcanii DS2, a model archaeon

Amber L. Hartman, Cédric Norais, Jonathan H. Badger, Stéphane Delmas, Sam Haldenby, Ramana Madupu, Jeffrey Robinson, Hoda Khouri, Qinghu Ren, Todd M. Lowe, Julie Maupin-Furlow, Mecky Pohlschroder, Charles Daniels, Friedhelm Pfeiffer, Thorsten Allers, Jonathan A Eisen

Research output: Contribution to journalArticlepeer-review

197 Scopus citations


Background: Haloferax volcanii is an easily culturable moderate halophile that grows on simple defined media, is readily transformable, and has a relatively stable genome. This, in combination with its biochemical and genetic tractability, has made Hfx. volcanii a key model organism, not only for the study of halophilicity, but also for archaeal biology in general. Methodology/Principal Findings: We report here the sequencing and analysis of the genome of Hfx. volcanii DS2, the type strain of this species. The genome contains a main 2.848 Mb chromosome, three smaller chromosomes pHV1, 3, 4 (85, 438, 636 kb, respectively) and the pHV2 plasmid (6.4 kb). Conclusions/Significance: The completed genome sequence, presented here, provides an invaluable tool for further in vivo and in vitro studies of Hfx. volcanii.

Original languageEnglish (US)
Article numbere9605
JournalPLoS One
Issue number3
StatePublished - 2010

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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