Abstract
The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes. The advent of genetic manipulation has created transgenic mice that develop hyperplasias and tumors morphologically and cytochemically comparable to lesions in humans. Even experienced pathologists have difficulty distinguishing between lesions from the two species, and the morphological similarities support the utility of the mouse model in understanding human breast cancer. In this essay we review our experience with the histopathology of human and mouse mammary disease by comparing the normal gland with hyperplastic, dysplastic and neoplastic lesions of traditional and transgenic origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-122 |
| Number of pages | 18 |
| Journal | Journal of Mammary Gland Biology and Neoplasia |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1999 |
Fingerprint
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
The comparative pathology of human and mouse mammary glands. / Cardiff, Robert; Wellings, S. R.
In: Journal of Mammary Gland Biology and Neoplasia, Vol. 4, No. 1, 01.01.1999, p. 105-122.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The comparative pathology of human and mouse mammary glands.
AU - Cardiff, Robert
AU - Wellings, S. R.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes. The advent of genetic manipulation has created transgenic mice that develop hyperplasias and tumors morphologically and cytochemically comparable to lesions in humans. Even experienced pathologists have difficulty distinguishing between lesions from the two species, and the morphological similarities support the utility of the mouse model in understanding human breast cancer. In this essay we review our experience with the histopathology of human and mouse mammary disease by comparing the normal gland with hyperplastic, dysplastic and neoplastic lesions of traditional and transgenic origin.
AB - The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes. The advent of genetic manipulation has created transgenic mice that develop hyperplasias and tumors morphologically and cytochemically comparable to lesions in humans. Even experienced pathologists have difficulty distinguishing between lesions from the two species, and the morphological similarities support the utility of the mouse model in understanding human breast cancer. In this essay we review our experience with the histopathology of human and mouse mammary disease by comparing the normal gland with hyperplastic, dysplastic and neoplastic lesions of traditional and transgenic origin.
UR - http://www.scopus.com/inward/record.url?scp=0032617467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032617467&partnerID=8YFLogxK
U2 - 10.1023/A:1018712905244
DO - 10.1023/A:1018712905244
M3 - Review article
C2 - 10219910
AN - SCOPUS:0032617467
VL - 4
SP - 105
EP - 122
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
SN - 1083-3021
IS - 1
ER -