The comparative aspects of hystricomorph subplacenta: potential endocrine organ

Maria Angelica Miglino, Gustavo de Sá Schiavo Matias, Nathia Nathaly Rigoglio, Jessica Borghesi, Taís Harumi de Castro Sasahara, Maria Josephina Illera del Portal, Juan Carlos Illera del Portal, Gema Silván Granado, Sara Cristina Caceres Ramos, Moacir Franco de Oliveira, Alan James Conley

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The placenta of hystricomorph rodents, lagomorphs and some primates includes an unusual structure, termed a subplacenta, which essentially consists of trophoblastic cells located deep to the central implantation site within the area of decidualization. It has been suggested that the subplacenta is functionally important, although considerable controversy remains on the issue. In this context, our objective was to compare the architecture and structure of the subplacentas of different hystricomorph species, to investigate the possibility that it is active in hormone synthesis. Methods: In total, the placentas of 3 capybaras (Hydrochaeris hydrochaeris), 2 pacas (Agouti paca), 5 agoutis (Dasyprocta leporina), 5 rock cavies (Kerodon rupestris) and 3 guinea pigs (Cavia porcellus) at different stages of pregnancy (early, middle and near term) were used for gross and microscopic examination. This included the preparation of latex injection casts, immunohistochemistry for steroidogenic enzymes, scanning and transmission electron microscopy. Tissue steroid concentrations were also determined. Results: The gross morphology and microvascular arrangement of the subplacentas were similar among the hystricomorphs studied including ultra-structural verification of cytotrophoblast and syncytiotrophoblast in all species. In guinea pigs, trophoblast cells exhibited characteristics consistent with intense metabolic and secretory activity in general. However, immuno-histochemical evidence also indicated that subplacental trophoblast expressed key steroidogenic enzymes, mainly in the chorionic villus region, consistent with tissue steroid concentrations. Conclusions: The subplacentas within placentas of hystricomorph rodent species are structurally similar and, in guinea pigs, have potential for steroid hormone secretion from, at least the early stages of pregnancy.

Original languageEnglish (US)
Article number16
JournalBMC Zoology
Volume6
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Agouti
  • Capybara
  • Hormones
  • Placentation
  • Rodents

ASJC Scopus subject areas

  • Animal Science and Zoology

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