The clone wars - revenge of the metastatic rogue state: The sarcoma paradigm

Holly L. Spraker, Shawn L. Price, Aashi Chaturvedi, Joshua D. Schiffman, Kevin B. Jones, Stephen L. Lessnick, Mary Beckerle, R Randall

Research output: Contribution to journalComment/debate

6 Scopus citations

Abstract

Ewing sarcoma (ES) is the second most common bone tumor affecting primarily adolescents and young adults. Despite recent advances in biological understanding, intensification of chemotherapeutic treatments, and progress in local control with surgery and/or radiation therapy, patients with metastatic or recurrent ES continue to have a dismal prognosis with less than 20% overall survival. All ES is likely metastatic at diagnosis although our methods of detection and classification may not account for this. Progressive disease may arise via a combination of: (1) selection of chemotherapy-resistant clones in primary tumor, (2) signaling from bone or lung microenvironments that may attract tumor cells to distant locations, and/or (3) genetic changes within the ES cells themselves due to DNA-damaging chemotherapeutic agents or other "hits." These possibilities and the evidence base to support them are explored.

Original languageEnglish (US)
Article number00002
JournalFrontiers in Oncology
Volume2
Issue numberJAN
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Keywords

  • Ewing sarcoma
  • Metastatic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Spraker, H. L., Price, S. L., Chaturvedi, A., Schiffman, J. D., Jones, K. B., Lessnick, S. L., Beckerle, M., & Randall, R. (2012). The clone wars - revenge of the metastatic rogue state: The sarcoma paradigm. Frontiers in Oncology, 2(JAN), [00002]. https://doi.org/10.3389/fonc.2012.00002