The clinical significance of IgA antimitochondrial antibodies in sera and saliva in primary biliary cirrhosis

Atsushi Tanaka, Saeko Nezu, Satoko Uegaki, Masaki Mikami, Shuhei Okuyama, Naohiro Kawamura, Mitsuhiko Aiso, M. Eric Gershwin, Shin Ichi Takahashi, Carlo Selmi, Hajime Takikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

26 Scopus citations

Abstract

It still remains unclear how antimitochondrial autoantibodies (AMA) are involved with immunopathogenesis of primary biliary cirrhosis (PBC). We have suggested the potential role of IgA-AMA in damage to epithelial cells in PBC. In the current study, we investigated whether IgA-AMA were detectable in sera and saliva of PBC patients, to examine the association between detectable IgA-type autoantibodies in sera or saliva and progression of liver diseases. Fifty-three patients with PBC were enrolled, and IgA-AMA in sera and saliva were sought by immunoblotting using pork heart mitochondria as antigens. The progression of PBC was determined as Scheuer's classification consisting of four histological stages. We found IgA-AMA, IgA-anti-PDC-E2, and IgA-anti-E3BP in 43/53 (81%), 37/53 (70%), and 35/53 (66%) sera of patients with PBC, but none of controls. The progression of PBC was statistically associated with presence of IgA-anti-PDC-E2 (P = 0.0124), but neither with IgA-AMA (P =0.1296) nor anti-IgA-E3BP (P =0.5973). In saliva, detectable IgA-AMA, IgA-anti-PDC-E2, and IgA-anti-E3BP were noted in 12/26 (46%), 6/26 (23%), and 11/26 (42%), respectively. Detection of IgA-anti-PDC-E2 was strongly associated with progression of PBC (P = 0.0002), whereas detection of IgA-AMA and IgA-anti-E3BP were not associated (P = 0.2145 and P = 0.5118). The current findings suggest that the presence of IgA-anti-PDC-E2 in sera or saliva might be associated with progression of PBC, although a prospective study with PBC patients with detectable IgA-anti-PDC-E2 at early stages will be required to conclude the contribution of IgA-anti-PDC-E2 to the progression of PBC.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages259-270
Number of pages12
Volume1107
DOIs
StatePublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1107
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • IgA-AMA
  • Mucosal immunity
  • Saliva

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Tanaka, A., Nezu, S., Uegaki, S., Mikami, M., Okuyama, S., Kawamura, N., Aiso, M., Gershwin, M. E., Takahashi, S. I., Selmi, C., & Takikawa, H. (2007). The clinical significance of IgA antimitochondrial antibodies in sera and saliva in primary biliary cirrhosis. In Annals of the New York Academy of Sciences (Vol. 1107, pp. 259-270). (Annals of the New York Academy of Sciences; Vol. 1107). https://doi.org/10.1196/annals.1381.028