Abstract
Basic investigations indicate variation among antibiotics in their propensity to release endotoxin from bacterial cells. Evidence for the clinical significance of this phenomenon includes: anecdotal reports; studies evaluating changes in endotoxin levels in response to antibiotics in a variety of infectious diseases; two studies which have prospectively evaluated changes in endotoxin levels in response to different antibiotics and correlated the changes with the patients' clinical course; and one study which evaluated differences in mortality in injured patients based on the endotoxin-releasing potential of antibiotics they received. These studies suggest: (i) different types of antibiotics do induce differing levels of endotoxin release during treatment of bacterial infections in humans; (ii) such antibiotic-associated endotoxin release probably does have a biologic consequence; and (iii) this biologic consequence is possibly of clinical relevance. However, the data are not sufficient to advocate changes in current antibiotic prescribing or dosing decisions. Rather, a variety of in vitro and in vivo experiments as well as clinical studies are advocated.
Original language | English (US) |
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Pages (from-to) | 253-259 |
Number of pages | 7 |
Journal | Innate Immunity |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Immunology
- Microbiology
- Infectious Diseases