The cholesterolemic effect of skim milk in young men consuming controlled diets

N. L. Keim, J. A. Marlett, C. H. Amundson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A 34-day metabolic study was conducted with nine healthy adult men to test the hypocholesterolemic action of skim milk (2 qt/day). Intakes of kilocalories, carbohydrate, protein, fat, cholesterol, calcium and dietary fiber were controlled, as were the ratios of polysaturated to saturated fat and animal protein to total protein in the diet. The study was comprised of three experimental periods: a high calcium control period (2600 mg/day), a low calcium control period (800 mg/day), and a high calcium skim milk period (2600 mg/day). Consumption of skim milk was associated with increases in plasma cholesterol levels, low density lipoprotein (LDL)-cholesterol and LDL-total lipid levels, and ratio of plasma cholesterol to high density lipoprotein (HDL)-cholesterol; and a decrease in HDL-cholesterol. A high dietary calcium intake was associated with a decrease in the plasma cholesterol to HDL-cholesterol ratio and an increase in triglyceride content of very low density lipoproteins. In this study, no hypocholesterolemic effect of fresh skim milk was observed when it was consumed along with a diet representative of a typical American diet pattern.

Original languageEnglish (US)
Pages (from-to)429-442
Number of pages14
JournalNutrition Research
Issue number5
StatePublished - 1981
Externally publishedYes


  • dietary calcium
  • high density lipoproteins
  • hypocholesterolemic milk factor
  • low density lipoproteins
  • plasma cholesterol
  • skim milk

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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