The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit Lam, Victor J. Hruby, Michal Lebl, Richard J. Knapp, Wieslaw M. Kazmierski, Evan M. Hersh, Sydney E. Salmon

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

A method is outlined for preparing large, diverse peptide libraries (105-107 peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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