The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit Lam; Victor J. Hruby; Michal Lebl; Richard J. Knapp; Wieslaw M. Kazmierski; Evan M. Hersh; Sydney E. Salmon

doi:10.1016/S0960-894X(01)80224-9

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit Lam, Victor J. Hruby, Michal Lebl, Richard J. Knapp, Wieslaw M. Kazmierski, Evan M. Hersh, Sydney E. Salmon

Research output: Contribution to journal › Article

66 Scopus citations

Abstract

A method is outlined for preparing large, diverse peptide libraries (10⁵-10⁷ peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.

Original language	English (US)
Pages (from-to)	419-424
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(01)80224-9
State	Published - 1993
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Lam, K., Hruby, V. J., Lebl, M., Knapp, R. J., Kazmierski, W. M., Hersh, E. M., & Salmon, S. E. (1993). The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors. Bioorganic and Medicinal Chemistry Letters, 3(3), 419-424. https://doi.org/10.1016/S0960-894X(01)80224-9

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors. / Lam, Kit; Hruby, Victor J.; Lebl, Michal; Knapp, Richard J.; Kazmierski, Wieslaw M.; Hersh, Evan M.; Salmon, Sydney E.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 3, 1993, p. 419-424.

Research output: Contribution to journal › Article

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10.1016/S0960-894X(01)80224-9