The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit Lam, Victor J. Hruby, Michal Lebl, Richard J. Knapp, Wieslaw M. Kazmierski, Evan M. Hersh, Sydney E. Salmon

Research output: Contribution to journal › Article

66 Citations (Scopus)

Abstract

A method is outlined for preparing large, diverse peptide libraries (105-107 peptides) such that there is one peptide per bead. These libraries can be used to screen for binding to macromolecular receptor (acceptor) molecules and to determine the structure of the peptides that bind.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

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Peptide Library
Ligands
Peptides
Libraries
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors. / Lam, Kit; Hruby, Victor J.; Lebl, Michal; Knapp, Richard J.; Kazmierski, Wieslaw M.; Hersh, Evan M.; Salmon, Sydney E.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 3, 1993, p. 419-424.

Research output: Contribution to journal › Article

Lam, K, Hruby, VJ, Lebl, M, Knapp, RJ, Kazmierski, WM, Hersh, EM & Salmon, SE 1993, 'The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors', Bioorganic and Medicinal Chemistry Letters, vol. 3, no. 3, pp. 419-424. https://doi.org/10.1016/S0960-894X(01)80224-9
Lam K, Hruby VJ, Lebl M, Knapp RJ, Kazmierski WM, Hersh EM et al. The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors. Bioorganic and Medicinal Chemistry Letters. 1993;3(3):419-424. https://doi.org/10.1016/S0960-894X(01)80224-9
Lam, Kit ; Hruby, Victor J. ; Lebl, Michal ; Knapp, Richard J. ; Kazmierski, Wieslaw M. ; Hersh, Evan M. ; Salmon, Sydney E. / The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors. In: Bioorganic and Medicinal Chemistry Letters. 1993 ; Vol. 3, No. 3. pp. 419-424.
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