Abstract
Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-naïve and castration-resistant PC.
| Original language | English (US) |
|---|---|
| Journal | Endocrine-Related Cancer |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- Androgen receptor
- Estrogen receptor β
- Hormone-naïve
- Prostate cancer
- Serine 210 phosphorylation
ASJC Scopus subject areas
- Endocrinology
- Oncology
- Cancer Research
- Endocrinology, Diabetes and Metabolism
Cite this
The changing roles of steroid nuclear receptors with prostate cancer progression. / Savoy, Rosalinda M.; Ghosh, Paramita M.
In: Endocrine-Related Cancer, Vol. 20, No. 4, 08.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The changing roles of steroid nuclear receptors with prostate cancer progression
AU - Savoy, Rosalinda M.
AU - Ghosh, Paramita M
PY - 2013/8
Y1 - 2013/8
N2 - Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-naïve and castration-resistant PC.
AB - Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-naïve and castration-resistant PC.
KW - Androgen receptor
KW - Estrogen receptor β
KW - Hormone-naïve
KW - Prostate cancer
KW - Serine 210 phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=84882797893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882797893&partnerID=8YFLogxK
U2 - 10.1530/ERC-13-0193
DO - 10.1530/ERC-13-0193
M3 - Article
VL - 20
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
SN - 1351-0088
IS - 4
ER -