The changing roles of steroid nuclear receptors with prostate cancer progression

Rosalinda M. Savoy, Paramita M Ghosh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-naïve and castration-resistant PC.

Original languageEnglish (US)
JournalEndocrine-Related Cancer
Volume20
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Steroid Receptors
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Estrogen Receptors
Endocrine Gland Neoplasms
Castration
Disease Progression
Estrogens
Hormones

Keywords

  • Androgen receptor
  • Estrogen receptor β
  • Hormone-naïve
  • Prostate cancer
  • Serine 210 phosphorylation

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

The changing roles of steroid nuclear receptors with prostate cancer progression. / Savoy, Rosalinda M.; Ghosh, Paramita M.

In: Endocrine-Related Cancer, Vol. 20, No. 4, 08.2013.

Research output: Contribution to journalArticle

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