The changing roles of steroid nuclear receptors with prostate cancer progression

Rosalinda M. Savoy; Paramita M Ghosh

doi:10.1530/ERC-13-0193

The changing roles of steroid nuclear receptors with prostate cancer progression

Rosalinda M. Savoy, Paramita M Ghosh

Urology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-naïve and castration-resistant PC.

Original language	English (US)
Journal	Endocrine-Related Cancer
Volume	20
Issue number	4
DOIs	https://doi.org/10.1530/ERC-13-0193
State	Published - Aug 2013

Keywords

Androgen receptor
Estrogen receptor β
Hormone-naïve
Prostate cancer
Serine 210 phosphorylation

ASJC Scopus subject areas

Endocrinology
Oncology
Cancer Research
Endocrinology, Diabetes and Metabolism

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title = "The changing roles of steroid nuclear receptors with prostate cancer progression",

abstract = "Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in various parts of the world to that effect. Recent developments in the understanding of a role for estrogen receptor b (ERb) in the development and progression of this disease resurrect the discussion on the intertwined roles of ER b and the androgen receptor (AR) in promoting PC. A new article by Zellweger et al. in Endocrine-Related Cancer investigates the expression and assesses the activity of ERa and ERb as well as the AR, in addition to a phosphorylated form of AR in hormone-na{\"i}ve and castration-resistant PC.",

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