The challenge of type 1 diabetes mellitus.

Larissa Eiselein, Henry J. Schwartz, John C Rutledge

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Diabetes mellitus is a heterogeneous group of diseases characterized by high blood glucose levels due to defects in insulin secretion, insulin action, or both. With the number of cases expected to increase rapidly in the years to come, diabetes is a growing health challenge worldwide. Of the approximately 16 million diabetics in the United States, about 1.5 million suffer from type 1 diabetes. In this catabolic disorder afflicting predominantly young individuals, blood insulin is almost completely absent, leading to hyperglycemia and alterations in lipid metabolism. Type 1 diabetes is thought to be induced by a toxic or infectious insult that occurs in genetically predisposed individuals. With recent advances in the understanding of the involved immunology and cellular and molecular mechanisms, researchers strive to battle the disease with new preventive and corrective strategies.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalILAR journal / National Research Council, Institute of Laboratory Animal Resources
Issue number3
StatePublished - 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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