Abstract
Background: Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX). Methods: This study is a prospective, randomized, blinded, clinical trial involving 59 healthy female dogs. An algometric pressure-measuring device was used to determine nociceptive threshold, and compared to three subjective pain scales. Group L/B received a line block of lidocaine (4 mg/kg) and bupivacaine (1 mg/kg) subcutaneously in the area of the incision site and saline subcutaneously as premedication; group L/BM (positive control) received a similar block and morphine (0.5 mg/kg) subcutaneously for premedication; and group SS (negative control) received a saline line block and saline premedication. Criteria for rescue analgesia were defined before the study. Dogs were assessed prior to surgery, at extubation (time 0) and at 2, 4, 6, 8 and 24 h post-recovery. The data were analyzed with one-way ANOVA, and a Split Plot RepeatedMeasures ANOVA with one grouping factor and one repeat factor (time). P < 0.05 was considered statistically significant. Results: Approximately 33% of dogs required rescue analgesia at some point during the study, with no significant difference between groups. There was no significant difference between treatment groups with any assessment method. Conclusions: As there were no statistically significant differences between positive and negative controls, the outcome of this technique cannot be proven.
| Original language | English (US) |
|---|---|
| Article number | e341 |
| Journal | PeerJ |
| Volume | 2014 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Bupivacaine
- Dog
- Lidocaine
- Local anesthesia
- Pain assessment
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
- Neuroscience(all)
Cite this
The challenge of evaluating pain and a pre-incisional local anesthetic block. / McKune, Carolyn M.; Pascoe, Peter J; Lascelles, B. Duncan X; Kass, Philip H.
In: PeerJ, Vol. 2014, No. 1, e341, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The challenge of evaluating pain and a pre-incisional local anesthetic block
AU - McKune, Carolyn M.
AU - Pascoe, Peter J
AU - Lascelles, B. Duncan X
AU - Kass, Philip H
PY - 2014
Y1 - 2014
N2 - Background: Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX). Methods: This study is a prospective, randomized, blinded, clinical trial involving 59 healthy female dogs. An algometric pressure-measuring device was used to determine nociceptive threshold, and compared to three subjective pain scales. Group L/B received a line block of lidocaine (4 mg/kg) and bupivacaine (1 mg/kg) subcutaneously in the area of the incision site and saline subcutaneously as premedication; group L/BM (positive control) received a similar block and morphine (0.5 mg/kg) subcutaneously for premedication; and group SS (negative control) received a saline line block and saline premedication. Criteria for rescue analgesia were defined before the study. Dogs were assessed prior to surgery, at extubation (time 0) and at 2, 4, 6, 8 and 24 h post-recovery. The data were analyzed with one-way ANOVA, and a Split Plot RepeatedMeasures ANOVA with one grouping factor and one repeat factor (time). P < 0.05 was considered statistically significant. Results: Approximately 33% of dogs required rescue analgesia at some point during the study, with no significant difference between groups. There was no significant difference between treatment groups with any assessment method. Conclusions: As there were no statistically significant differences between positive and negative controls, the outcome of this technique cannot be proven.
AB - Background: Our objective was to test the effectiveness of a local anesthetic line block administered before surgery in reducing postoperative pain scores in dogs undergoing ovariohysterectomy (OVHX). Methods: This study is a prospective, randomized, blinded, clinical trial involving 59 healthy female dogs. An algometric pressure-measuring device was used to determine nociceptive threshold, and compared to three subjective pain scales. Group L/B received a line block of lidocaine (4 mg/kg) and bupivacaine (1 mg/kg) subcutaneously in the area of the incision site and saline subcutaneously as premedication; group L/BM (positive control) received a similar block and morphine (0.5 mg/kg) subcutaneously for premedication; and group SS (negative control) received a saline line block and saline premedication. Criteria for rescue analgesia were defined before the study. Dogs were assessed prior to surgery, at extubation (time 0) and at 2, 4, 6, 8 and 24 h post-recovery. The data were analyzed with one-way ANOVA, and a Split Plot RepeatedMeasures ANOVA with one grouping factor and one repeat factor (time). P < 0.05 was considered statistically significant. Results: Approximately 33% of dogs required rescue analgesia at some point during the study, with no significant difference between groups. There was no significant difference between treatment groups with any assessment method. Conclusions: As there were no statistically significant differences between positive and negative controls, the outcome of this technique cannot be proven.
KW - Bupivacaine
KW - Dog
KW - Lidocaine
KW - Local anesthesia
KW - Pain assessment
UR - http://www.scopus.com/inward/record.url?scp=84899083995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899083995&partnerID=8YFLogxK
U2 - 10.7717/peerj.341
DO - 10.7717/peerj.341
M3 - Article
VL - 2014
JO - PeerJ
JF - PeerJ
SN - 2167-8359
IS - 1
M1 - e341
ER -