The centrosome cycle

Christopher P. Mattison, Mark Winey

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are conserved. Experimental analysis has provided an outline to describe centrosome duplication, and numerous centrosome components have been identified. Even so, more work is needed to provide a detailed understanding of the interactions between centrosome components and their roles in centrosome function and duplication. Precise duplication of centrosomes once during each cell cycle ensures proper mitotic spindle formation and chromosome segregation. Defects in centrosome duplication or function are linked to human diseases including cancer. Here we provide amultifaceted look at centrosomes with a detailed summary of the centrosome cycle.

Original languageEnglish (US)
Title of host publicationCell Cycle Regulation
EditorsPhilipp Kaldiss
Number of pages36
StatePublished - Dec 11 2006
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'The centrosome cycle'. Together they form a unique fingerprint.

Cite this