The centrosome cycle

Christopher P. Mattison, Mark Winey

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are conserved. Experimental analysis has provided an outline to describe centrosome duplication, and numerous centrosome components have been identified. Even so, more work is needed to provide a detailed understanding of the interactions between centrosome components and their roles in centrosome function and duplication. Precise duplication of centrosomes once during each cell cycle ensures proper mitotic spindle formation and chromosome segregation. Defects in centrosome duplication or function are linked to human diseases including cancer. Here we provide amultifaceted look at centrosomes with a detailed summary of the centrosome cycle.

Original languageEnglish (US)
Title of host publicationCell Cycle Regulation
EditorsPhilipp Kaldiss
Pages111-146
Number of pages36
DOIs
StatePublished - Dec 11 2006
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
Volume42
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

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ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Mattison, C. P., & Winey, M. (2006). The centrosome cycle. In P. Kaldiss (Ed.), Cell Cycle Regulation (pp. 111-146). (Results and Problems in Cell Differentiation; Vol. 42). https://doi.org/10.1007/b136685