The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease

Viola L. Sampson, John Morrison, James C. Vickers

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The vulnerability of nerve cells to the neurofibrillary pathology of Alzheimer's disease (AD) may be determined by the presence within them of certain cytoskeletal proteins. Fluorescence multiple labeling was used to assess the vulnerability of two separate subpopulations of nonpyramidal neurons in the superior frontal gyrus, distinguished by their content of the calcium-binding proteins parvalbumin (PV) and calretinin (CR), to the neuropathology of AD. In AD, counterstaining PV- and CR-labeled sections with thioflavine S demonstrated that the great majority of these cells did not contain neurofibrillary tangles, except for the large CR-immunoreactive neurons in layer I. This latter group of cells was also characterized as containing neurofilament (NF) triplet proteins, whereas other CR-labeled cortical neurons were not immunoreactive for NF. There was also a small AD- related increase in the proportion of PV-labeled cells showing NF protein immunoreactivity (1-9% of the total population in AD cases compared to 0- 0.4% in non-AD cases), which likewise may be linked to the susceptibility of a minute proportion (0-0.7%) of these neurons to form neurofibrillary tangles in AD. These data are further evidence that the presence of NF in cortical nerve cells is linked to their vulnerability to the pathological process underlying AD.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalExperimental Neurology
Volume145
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Calbindin 2
Parvalbumins
Alzheimer Disease
Pathology
Neurons
Neurofilament Proteins
Neurofibrillary Tangles
Intermediate Filaments
Calcium-Binding Proteins
Cytoskeletal Proteins
Pathologic Processes
Prefrontal Cortex
Fluorescence

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease. / Sampson, Viola L.; Morrison, John; Vickers, James C.

In: Experimental Neurology, Vol. 145, No. 1, 01.01.1997, p. 295-302.

Research output: Contribution to journalArticle

@article{39064d5d3077429ab94b4568efd829c8,
title = "The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease",
abstract = "The vulnerability of nerve cells to the neurofibrillary pathology of Alzheimer's disease (AD) may be determined by the presence within them of certain cytoskeletal proteins. Fluorescence multiple labeling was used to assess the vulnerability of two separate subpopulations of nonpyramidal neurons in the superior frontal gyrus, distinguished by their content of the calcium-binding proteins parvalbumin (PV) and calretinin (CR), to the neuropathology of AD. In AD, counterstaining PV- and CR-labeled sections with thioflavine S demonstrated that the great majority of these cells did not contain neurofibrillary tangles, except for the large CR-immunoreactive neurons in layer I. This latter group of cells was also characterized as containing neurofilament (NF) triplet proteins, whereas other CR-labeled cortical neurons were not immunoreactive for NF. There was also a small AD- related increase in the proportion of PV-labeled cells showing NF protein immunoreactivity (1-9{\%} of the total population in AD cases compared to 0- 0.4{\%} in non-AD cases), which likewise may be linked to the susceptibility of a minute proportion (0-0.7{\%}) of these neurons to form neurofibrillary tangles in AD. These data are further evidence that the presence of NF in cortical nerve cells is linked to their vulnerability to the pathological process underlying AD.",
author = "Sampson, {Viola L.} and John Morrison and Vickers, {James C.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1006/exnr.1997.6433",
language = "English (US)",
volume = "145",
pages = "295--302",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease

AU - Sampson, Viola L.

AU - Morrison, John

AU - Vickers, James C.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The vulnerability of nerve cells to the neurofibrillary pathology of Alzheimer's disease (AD) may be determined by the presence within them of certain cytoskeletal proteins. Fluorescence multiple labeling was used to assess the vulnerability of two separate subpopulations of nonpyramidal neurons in the superior frontal gyrus, distinguished by their content of the calcium-binding proteins parvalbumin (PV) and calretinin (CR), to the neuropathology of AD. In AD, counterstaining PV- and CR-labeled sections with thioflavine S demonstrated that the great majority of these cells did not contain neurofibrillary tangles, except for the large CR-immunoreactive neurons in layer I. This latter group of cells was also characterized as containing neurofilament (NF) triplet proteins, whereas other CR-labeled cortical neurons were not immunoreactive for NF. There was also a small AD- related increase in the proportion of PV-labeled cells showing NF protein immunoreactivity (1-9% of the total population in AD cases compared to 0- 0.4% in non-AD cases), which likewise may be linked to the susceptibility of a minute proportion (0-0.7%) of these neurons to form neurofibrillary tangles in AD. These data are further evidence that the presence of NF in cortical nerve cells is linked to their vulnerability to the pathological process underlying AD.

AB - The vulnerability of nerve cells to the neurofibrillary pathology of Alzheimer's disease (AD) may be determined by the presence within them of certain cytoskeletal proteins. Fluorescence multiple labeling was used to assess the vulnerability of two separate subpopulations of nonpyramidal neurons in the superior frontal gyrus, distinguished by their content of the calcium-binding proteins parvalbumin (PV) and calretinin (CR), to the neuropathology of AD. In AD, counterstaining PV- and CR-labeled sections with thioflavine S demonstrated that the great majority of these cells did not contain neurofibrillary tangles, except for the large CR-immunoreactive neurons in layer I. This latter group of cells was also characterized as containing neurofilament (NF) triplet proteins, whereas other CR-labeled cortical neurons were not immunoreactive for NF. There was also a small AD- related increase in the proportion of PV-labeled cells showing NF protein immunoreactivity (1-9% of the total population in AD cases compared to 0- 0.4% in non-AD cases), which likewise may be linked to the susceptibility of a minute proportion (0-0.7%) of these neurons to form neurofibrillary tangles in AD. These data are further evidence that the presence of NF in cortical nerve cells is linked to their vulnerability to the pathological process underlying AD.

UR - http://www.scopus.com/inward/record.url?scp=0031149760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031149760&partnerID=8YFLogxK

U2 - 10.1006/exnr.1997.6433

DO - 10.1006/exnr.1997.6433

M3 - Article

C2 - 9184132

AN - SCOPUS:0031149760

VL - 145

SP - 295

EP - 302

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -