The cellular and molecular basis of store-operated calcium entry

Katrik Venkatachalam, Damian B. van Rossum, Randen L. Patterson, Hong Tao Ma, Donald L. Gill

Research output: Contribution to journalArticle

324 Scopus citations

Abstract

The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

Original languageEnglish (US)
JournalNature Cell Biology
Volume4
Issue number11
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'The cellular and molecular basis of store-operated calcium entry'. Together they form a unique fingerprint.

  • Cite this

    Venkatachalam, K., van Rossum, D. B., Patterson, R. L., Ma, H. T., & Gill, D. L. (2002). The cellular and molecular basis of store-operated calcium entry. Nature Cell Biology, 4(11). https://doi.org/10.1038/ncb1102-e263