Abstract
The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
| Original language | English (US) |
|---|---|
| Journal | Nature Cell Biology |
| Volume | 4 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
The cellular and molecular basis of store-operated calcium entry. / Venkatachalam, Katrik; van Rossum, Damian B.; Patterson, Randen L.; Ma, Hong Tao; Gill, Donald L.
In: Nature Cell Biology, Vol. 4, No. 11, 01.11.2002.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The cellular and molecular basis of store-operated calcium entry
AU - Venkatachalam, Katrik
AU - van Rossum, Damian B.
AU - Patterson, Randen L.
AU - Ma, Hong Tao
AU - Gill, Donald L.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
AB - The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036847977&partnerID=8YFLogxK
U2 - 10.1038/ncb1102-e263
DO - 10.1038/ncb1102-e263
M3 - Article
C2 - 12415286
AN - SCOPUS:0036847977
VL - 4
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 11
ER -