The cellular and molecular basis of store-operated calcium entry

Katrik Venkatachalam, Damian B. van Rossum, Randen L. Patterson, Hong Tao Ma, Donald L. Gill

Research output: Contribution to journalArticle

321 Citations (Scopus)

Abstract

The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

Original languageEnglish (US)
JournalNature Cell Biology
Volume4
Issue number11
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Calcium
Calcium Signaling
Calcium Channels
Endoplasmic Reticulum
Cell Biology
Cell Membrane

ASJC Scopus subject areas

  • Cell Biology

Cite this

Venkatachalam, K., van Rossum, D. B., Patterson, R. L., Ma, H. T., & Gill, D. L. (2002). The cellular and molecular basis of store-operated calcium entry. Nature Cell Biology, 4(11). https://doi.org/10.1038/ncb1102-e263

The cellular and molecular basis of store-operated calcium entry. / Venkatachalam, Katrik; van Rossum, Damian B.; Patterson, Randen L.; Ma, Hong Tao; Gill, Donald L.

In: Nature Cell Biology, Vol. 4, No. 11, 01.11.2002.

Research output: Contribution to journalArticle

Venkatachalam, K, van Rossum, DB, Patterson, RL, Ma, HT & Gill, DL 2002, 'The cellular and molecular basis of store-operated calcium entry', Nature Cell Biology, vol. 4, no. 11. https://doi.org/10.1038/ncb1102-e263
Venkatachalam K, van Rossum DB, Patterson RL, Ma HT, Gill DL. The cellular and molecular basis of store-operated calcium entry. Nature Cell Biology. 2002 Nov 1;4(11). https://doi.org/10.1038/ncb1102-e263
Venkatachalam, Katrik ; van Rossum, Damian B. ; Patterson, Randen L. ; Ma, Hong Tao ; Gill, Donald L. / The cellular and molecular basis of store-operated calcium entry. In: Nature Cell Biology. 2002 ; Vol. 4, No. 11.
@article{8579ecef5c67403f92707d193bf8eff4,
title = "The cellular and molecular basis of store-operated calcium entry",
abstract = "The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.",
author = "Katrik Venkatachalam and {van Rossum}, {Damian B.} and Patterson, {Randen L.} and Ma, {Hong Tao} and Gill, {Donald L.}",
year = "2002",
month = "11",
day = "1",
doi = "10.1038/ncb1102-e263",
language = "English (US)",
volume = "4",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - The cellular and molecular basis of store-operated calcium entry

AU - Venkatachalam, Katrik

AU - van Rossum, Damian B.

AU - Patterson, Randen L.

AU - Ma, Hong Tao

AU - Gill, Donald L.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

AB - The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals - the activation of 'store-operated channels' (SOCs) - remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.

UR - http://www.scopus.com/inward/record.url?scp=0036847977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036847977&partnerID=8YFLogxK

U2 - 10.1038/ncb1102-e263

DO - 10.1038/ncb1102-e263

M3 - Article

C2 - 12415286

AN - SCOPUS:0036847977

VL - 4

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 11

ER -