Abstract
CI-988, a water-soluble, selective cholecystokinin-B antagonist, was perfused through a microdialysis probe into the anterior nucleus accumbens, posterior nucleus accumbens, or caudate nucleus of anesthetized rats. High concentrations of CI-988 produced three- to fivefold increases in dopamine overflow, at all three sites, that were temporally correlated with the CI- 988 perfusion and returned to baseline levels upon cessation of CI-988 perfusion. However, the cholecystokinin-A antagonist CAM-1481, and the relatively inactive enantiomer of CI-988, CAM-1241, also increased dopamine overflow in the nucleus accumbens. Furthermore, the ability of CI-988 to increase dopamine overflow persisted in the absence of calcium in the perfusate and was not sensitive to tetrodotoxin treatment. The mechanism by which locally administered CI-988 increases dopamine overflow appears not to be anatomically specific, not selective for one cholecystokinin receptor subtype, and may be nonvesicular.
Original language | English (US) |
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Pages (from-to) | 208-217 |
Number of pages | 10 |
Journal | Journal of Neurochemistry |
Volume | 65 |
Issue number | 1 |
State | Published - Jul 1995 |
Externally published | Yes |
Keywords
- Cholecystokinin
- In vivo microdialysis
- Mesolimbic
- Neuropeptide
- Receptor
- Release
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience