The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput, Jose M. Ordovas, Lynnette Ferguson, Ben van Ommen, Raymond L. Rodriguez, Lindsay Allen, Bruce N. Ames, Kevin Dawson, Bruce German, Ronald Krauss, Wasyl Malyj, Michael C. Archer, Stephen Barnes, Amelia Bortholomew, Ruth Birk, Peter van Bladeren, Kent J. Bradford, Kenneth H. Brown, Rosane Caetano, David CastleRuth Chadwick, Stephen Clarke, Karine Clemént, Craig A. Cooney, Dolores Corella, Ivana Beatrice Manica da Cruz, Hannelore Daniel, Troy Duster, Sven O E Ebbesson, Ruan Elliott, Susan Fairweather-Tait, Jim Felton, Michael Fenech, John W. Finley, Nancy Fogg-Johnson, Rosalynn Gill-Garrison, Michael J. Gibney, Peter J. Gillies, Jan Ake Gustafsson, John L. Hartman IV, Lin He, Jae Kwan Hwang, Jean Philippe Jais, Yangsoo Jang, Hans Joost, Claudine Junien, Mitchell Kanter, Warren A. Kibbe, Berthold Koletzko, Bruce R. Korf, Kenneth Kornman, David W. Krempin, Dominique Langin, Dennis R. Lauren, Jong Ho Lee, Gilbert A. Leveille, Su Ju Lin, John Mathers, Michael Mayne, Warren McNabb, John A. Milner, Peter Morgan, Michael Muller, Yuri Nikolsky, Frans van der Ouderaa, Taesun Park, Norma Pensel, Francisco Perez-Jimenez, Kaisa Poutanen, Matthew Roberts, Wim H M Saris, Gertrud Schuster, Andrew N. Shelling, Artemis P. Simopoulos, Sue Southon, E. Shyong Tai, Bradford Towne, Paul Trayhurn, Ricardo Uauy, Willard J. Visek, Craig H Warden, Rick Weiss, John Wiencke, Jack Winkler, George L. Wolff, Xi Zhao-Wilson, Jean Daniel Zucker

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Original languageEnglish (US)
Pages (from-to)623-632
Number of pages10
JournalBritish Journal of Nutrition
Volume94
Issue number5
DOIs
StatePublished - Nov 2005

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Nutrigenomics
Public Health
Food
Genes
Medical Genetics
Developed Countries
Developing Countries
Epidemiologic Studies
Molecular Biology
Chronic Disease
Genotype
Research Personnel
Diet
Phenotype
Health
Population

Keywords

  • Gene-nutrient interactions
  • Health diaparities
  • Nutrigenomics
  • Strategic international alliances

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Kaput, J., Ordovas, J. M., Ferguson, L., van Ommen, B., Rodriguez, R. L., Allen, L., ... Zucker, J. D. (2005). The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition, 94(5), 623-632. https://doi.org/10.1079/BJN20051585

The case for strategic international alliances to harness nutritional genomics for public and personal health. / Kaput, Jim; Ordovas, Jose M.; Ferguson, Lynnette; van Ommen, Ben; Rodriguez, Raymond L.; Allen, Lindsay; Ames, Bruce N.; Dawson, Kevin; German, Bruce; Krauss, Ronald; Malyj, Wasyl; Archer, Michael C.; Barnes, Stephen; Bortholomew, Amelia; Birk, Ruth; van Bladeren, Peter; Bradford, Kent J.; Brown, Kenneth H.; Caetano, Rosane; Castle, David; Chadwick, Ruth; Clarke, Stephen; Clemént, Karine; Cooney, Craig A.; Corella, Dolores; da Cruz, Ivana Beatrice Manica; Daniel, Hannelore; Duster, Troy; Ebbesson, Sven O E; Elliott, Ruan; Fairweather-Tait, Susan; Felton, Jim; Fenech, Michael; Finley, John W.; Fogg-Johnson, Nancy; Gill-Garrison, Rosalynn; Gibney, Michael J.; Gillies, Peter J.; Gustafsson, Jan Ake; Hartman IV, John L.; He, Lin; Hwang, Jae Kwan; Jais, Jean Philippe; Jang, Yangsoo; Joost, Hans; Junien, Claudine; Kanter, Mitchell; Kibbe, Warren A.; Koletzko, Berthold; Korf, Bruce R.; Kornman, Kenneth; Krempin, David W.; Langin, Dominique; Lauren, Dennis R.; Lee, Jong Ho; Leveille, Gilbert A.; Lin, Su Ju; Mathers, John; Mayne, Michael; McNabb, Warren; Milner, John A.; Morgan, Peter; Muller, Michael; Nikolsky, Yuri; van der Ouderaa, Frans; Park, Taesun; Pensel, Norma; Perez-Jimenez, Francisco; Poutanen, Kaisa; Roberts, Matthew; Saris, Wim H M; Schuster, Gertrud; Shelling, Andrew N.; Simopoulos, Artemis P.; Southon, Sue; Shyong Tai, E.; Towne, Bradford; Trayhurn, Paul; Uauy, Ricardo; Visek, Willard J.; Warden, Craig H; Weiss, Rick; Wiencke, John; Winkler, Jack; Wolff, George L.; Zhao-Wilson, Xi; Zucker, Jean Daniel.

In: British Journal of Nutrition, Vol. 94, No. 5, 11.2005, p. 623-632.

Research output: Contribution to journalArticle

Kaput, J, Ordovas, JM, Ferguson, L, van Ommen, B, Rodriguez, RL, Allen, L, Ames, BN, Dawson, K, German, B, Krauss, R, Malyj, W, Archer, MC, Barnes, S, Bortholomew, A, Birk, R, van Bladeren, P, Bradford, KJ, Brown, KH, Caetano, R, Castle, D, Chadwick, R, Clarke, S, Clemént, K, Cooney, CA, Corella, D, da Cruz, IBM, Daniel, H, Duster, T, Ebbesson, SOE, Elliott, R, Fairweather-Tait, S, Felton, J, Fenech, M, Finley, JW, Fogg-Johnson, N, Gill-Garrison, R, Gibney, MJ, Gillies, PJ, Gustafsson, JA, Hartman IV, JL, He, L, Hwang, JK, Jais, JP, Jang, Y, Joost, H, Junien, C, Kanter, M, Kibbe, WA, Koletzko, B, Korf, BR, Kornman, K, Krempin, DW, Langin, D, Lauren, DR, Lee, JH, Leveille, GA, Lin, SJ, Mathers, J, Mayne, M, McNabb, W, Milner, JA, Morgan, P, Muller, M, Nikolsky, Y, van der Ouderaa, F, Park, T, Pensel, N, Perez-Jimenez, F, Poutanen, K, Roberts, M, Saris, WHM, Schuster, G, Shelling, AN, Simopoulos, AP, Southon, S, Shyong Tai, E, Towne, B, Trayhurn, P, Uauy, R, Visek, WJ, Warden, CH, Weiss, R, Wiencke, J, Winkler, J, Wolff, GL, Zhao-Wilson, X & Zucker, JD 2005, 'The case for strategic international alliances to harness nutritional genomics for public and personal health', British Journal of Nutrition, vol. 94, no. 5, pp. 623-632. https://doi.org/10.1079/BJN20051585
Kaput, Jim ; Ordovas, Jose M. ; Ferguson, Lynnette ; van Ommen, Ben ; Rodriguez, Raymond L. ; Allen, Lindsay ; Ames, Bruce N. ; Dawson, Kevin ; German, Bruce ; Krauss, Ronald ; Malyj, Wasyl ; Archer, Michael C. ; Barnes, Stephen ; Bortholomew, Amelia ; Birk, Ruth ; van Bladeren, Peter ; Bradford, Kent J. ; Brown, Kenneth H. ; Caetano, Rosane ; Castle, David ; Chadwick, Ruth ; Clarke, Stephen ; Clemént, Karine ; Cooney, Craig A. ; Corella, Dolores ; da Cruz, Ivana Beatrice Manica ; Daniel, Hannelore ; Duster, Troy ; Ebbesson, Sven O E ; Elliott, Ruan ; Fairweather-Tait, Susan ; Felton, Jim ; Fenech, Michael ; Finley, John W. ; Fogg-Johnson, Nancy ; Gill-Garrison, Rosalynn ; Gibney, Michael J. ; Gillies, Peter J. ; Gustafsson, Jan Ake ; Hartman IV, John L. ; He, Lin ; Hwang, Jae Kwan ; Jais, Jean Philippe ; Jang, Yangsoo ; Joost, Hans ; Junien, Claudine ; Kanter, Mitchell ; Kibbe, Warren A. ; Koletzko, Berthold ; Korf, Bruce R. ; Kornman, Kenneth ; Krempin, David W. ; Langin, Dominique ; Lauren, Dennis R. ; Lee, Jong Ho ; Leveille, Gilbert A. ; Lin, Su Ju ; Mathers, John ; Mayne, Michael ; McNabb, Warren ; Milner, John A. ; Morgan, Peter ; Muller, Michael ; Nikolsky, Yuri ; van der Ouderaa, Frans ; Park, Taesun ; Pensel, Norma ; Perez-Jimenez, Francisco ; Poutanen, Kaisa ; Roberts, Matthew ; Saris, Wim H M ; Schuster, Gertrud ; Shelling, Andrew N. ; Simopoulos, Artemis P. ; Southon, Sue ; Shyong Tai, E. ; Towne, Bradford ; Trayhurn, Paul ; Uauy, Ricardo ; Visek, Willard J. ; Warden, Craig H ; Weiss, Rick ; Wiencke, John ; Winkler, Jack ; Wolff, George L. ; Zhao-Wilson, Xi ; Zucker, Jean Daniel. / The case for strategic international alliances to harness nutritional genomics for public and personal health. In: British Journal of Nutrition. 2005 ; Vol. 94, No. 5. pp. 623-632.
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