The carcinogenic potential of the gas phase of environmental tobacco smoke

Hanspeter Witschi, Imelda Espiritu, Robert R. Maronpot, Kent E Pinkerton, A. Daniel Jones

Research output: Contribution to journalArticle

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Abstract

Female strain A/J mice were exposed to unfiltered or HEPA-filtered environmental tobacco smoke (ETS). Total suspended particulates (TSP) in the full smoke exposure chamber was 78.5 mg/m3 and in the filtered smoke chamber 0.1 mg/m3; nicotine concentrations in the full and filtered smoke chamber were 13.4 and 3.1 mg/m3, respectively. Animals exposed to filtered ETS (6 h a day, 5 days a week) and killed after 5 months had a higher lung tumor incidence and multiplicity than controls maintained in filtered air, although the differences were not statistically significant. Animals exposed to filtered and full ETS and allowed to recover in air for 4 months had an average of 1.2 ± 0.3 tumors per lung and 1.3 ± 0.3 tumors per lung, respectively. Air exposed control animals had an average tumor multiplicity 0.5 ± 0.1 tumors per lung. Increased immunstaining for CYP 1A1 was not evident in the lung of animals exposed to filtered smoke. Based on the chamber concentrations of selected nitrosamines and polycyclic aromatic hydrocarbons, the possible maximum uptakes by the mice of NNK, NNN and benzo[a]pyrene during the 5 months exposure period were three to six orders of magnitude below doses reported in the literature to produce 1 lung tumor in strain A/J mice. It was concluded that the gas phase of ETS is as carcinogenic as is full ETS. The carcinogenicity of the gas phase may be due to some as yet unidentified, yet highly potent carcinogens or by placing a substantial, possibly free radical-mediated oxidative stress on the lung.

Original languageEnglish (US)
Pages (from-to)2035-2042
Number of pages8
JournalCarcinogenesis
Volume18
Issue number11
DOIs
StatePublished - Nov 1997
Externally publishedYes

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Smoke
Tobacco
Gases
Lung
Neoplasms
Air
Nitrosamines
Cytochrome P-450 CYP1A1
Benzo(a)pyrene
Polycyclic Aromatic Hydrocarbons
Nicotine
Carcinogens
Free Radicals
Oxidative Stress
Incidence

ASJC Scopus subject areas

  • Cancer Research

Cite this

The carcinogenic potential of the gas phase of environmental tobacco smoke. / Witschi, Hanspeter; Espiritu, Imelda; Maronpot, Robert R.; Pinkerton, Kent E; Daniel Jones, A.

In: Carcinogenesis, Vol. 18, No. 11, 11.1997, p. 2035-2042.

Research output: Contribution to journalArticle

Witschi, H, Espiritu, I, Maronpot, RR, Pinkerton, KE & Daniel Jones, A 1997, 'The carcinogenic potential of the gas phase of environmental tobacco smoke', Carcinogenesis, vol. 18, no. 11, pp. 2035-2042. https://doi.org/10.1093/carcin/18.11.2035
Witschi, Hanspeter ; Espiritu, Imelda ; Maronpot, Robert R. ; Pinkerton, Kent E ; Daniel Jones, A. / The carcinogenic potential of the gas phase of environmental tobacco smoke. In: Carcinogenesis. 1997 ; Vol. 18, No. 11. pp. 2035-2042.
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