The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats

Raymond P. Kesner, Michael R. Hunsaker, Matthew W. Warthen

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80% correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks.

Original languageEnglish (US)
Pages (from-to)1217-1225
Number of pages9
JournalBehavioral Neuroscience
Volume122
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Association Learning
Episodic Memory
Hippocampus

Keywords

  • arbitrary association
  • CA3
  • episodic memory
  • hippocampus
  • paired-associate learning

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats. / Kesner, Raymond P.; Hunsaker, Michael R.; Warthen, Matthew W.

In: Behavioral Neuroscience, Vol. 122, No. 6, 12.2008, p. 1217-1225.

Research output: Contribution to journalArticle

Kesner, Raymond P. ; Hunsaker, Michael R. ; Warthen, Matthew W. / The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats. In: Behavioral Neuroscience. 2008 ; Vol. 122, No. 6. pp. 1217-1225.
@article{44b868fe9ba843e982fed1d6f07f2067,
title = "The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats",
abstract = "This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80{\%} correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks.",
keywords = "arbitrary association, CA3, episodic memory, hippocampus, paired-associate learning",
author = "Kesner, {Raymond P.} and Hunsaker, {Michael R.} and Warthen, {Matthew W.}",
year = "2008",
month = "12",
doi = "10.1037/a0013592",
language = "English (US)",
volume = "122",
pages = "1217--1225",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "6",

}

TY - JOUR

T1 - The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing by Means of Relational Encoding in Rats

AU - Kesner, Raymond P.

AU - Hunsaker, Michael R.

AU - Warthen, Matthew W.

PY - 2008/12

Y1 - 2008/12

N2 - This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80% correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks.

AB - This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80% correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks.

KW - arbitrary association

KW - CA3

KW - episodic memory

KW - hippocampus

KW - paired-associate learning

UR - http://www.scopus.com/inward/record.url?scp=57049090016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57049090016&partnerID=8YFLogxK

U2 - 10.1037/a0013592

DO - 10.1037/a0013592

M3 - Article

VL - 122

SP - 1217

EP - 1225

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 6

ER -