Abstract
The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course. Neural circuitry, molecular profiles, and neurochemistry can be changed by experiences, which influence behavior as well as neuroendocrine and autonomic function. Such effects have a particular impact during infancy and in adolescence. Behavioral stress affects both the structure and function of PFC, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued. During aging, neurons within the PFC become less resilient to stress. There are also sex differences in the PFC response to stressors. While such stress and sex hormone-related alterations occur in regions mediating the highest levels of cognitive function and self-regulatory control, the fact that they are not necessarily permanent has implications for future behavior-based therapies that harness neural plasticity for recovery
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16-29 |
| Number of pages | 14 |
| Journal | Neuron |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 10 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The Brain on Stress : Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course. / McEwen, Bruce S.; Morrison, John.
In: Neuron, Vol. 79, No. 1, 10.07.2013, p. 16-29.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Brain on Stress
T2 - Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
AU - McEwen, Bruce S.
AU - Morrison, John
PY - 2013/7/10
Y1 - 2013/7/10
N2 - The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course. Neural circuitry, molecular profiles, and neurochemistry can be changed by experiences, which influence behavior as well as neuroendocrine and autonomic function. Such effects have a particular impact during infancy and in adolescence. Behavioral stress affects both the structure and function of PFC, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued. During aging, neurons within the PFC become less resilient to stress. There are also sex differences in the PFC response to stressors. While such stress and sex hormone-related alterations occur in regions mediating the highest levels of cognitive function and self-regulatory control, the fact that they are not necessarily permanent has implications for future behavior-based therapies that harness neural plasticity for recovery
AB - The prefrontal cortex (PFC) is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course. Neural circuitry, molecular profiles, and neurochemistry can be changed by experiences, which influence behavior as well as neuroendocrine and autonomic function. Such effects have a particular impact during infancy and in adolescence. Behavioral stress affects both the structure and function of PFC, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued. During aging, neurons within the PFC become less resilient to stress. There are also sex differences in the PFC response to stressors. While such stress and sex hormone-related alterations occur in regions mediating the highest levels of cognitive function and self-regulatory control, the fact that they are not necessarily permanent has implications for future behavior-based therapies that harness neural plasticity for recovery
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UR - http://www.scopus.com/inward/citedby.url?scp=84880008715&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2013.06.028
DO - 10.1016/j.neuron.2013.06.028
M3 - Review article
VL - 79
SP - 16
EP - 29
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -