Abstract
Systemic kainic acid (KA) at 1 mg/kg crosses the normal blood-brain barrier (BBB) of rats to produce scattered sharp waves for ~10 min on the EEG, but is without observable effect, producing no EEG or behavioral changes, at 0.5 mg/kg. When the BBB is opened in most of one hemisphere by 6,000 rads, the rats are clinically normal and have a normal EEG. When the irradiated rats are challenged with 0.5 mg/kg KA, intense, highly lateralized epileptiform bursts result; these bursts last 1-10 s and recur for 90 mins. This phenomenon is repeatable for the 1 week that the BBB is open. The results are identical when the BBB is opened with a pin lesion. Because endogenous glutamate agonists are common, these data suggest a possible pathophysiologic mechanism for human epilepsy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 574-577 |
| Number of pages | 4 |
| Journal | Epilepsia |
| Volume | 25 |
| Issue number | 5 |
| State | Published - 1984 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
The blood-brain barrier lesion and the systemic convulsant model of epilepsy. / Remler, M. P.; Marcussen, W. H.
In: Epilepsia, Vol. 25, No. 5, 1984, p. 574-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The blood-brain barrier lesion and the systemic convulsant model of epilepsy
AU - Remler, M. P.
AU - Marcussen, W. H.
PY - 1984
Y1 - 1984
N2 - Systemic kainic acid (KA) at 1 mg/kg crosses the normal blood-brain barrier (BBB) of rats to produce scattered sharp waves for ~10 min on the EEG, but is without observable effect, producing no EEG or behavioral changes, at 0.5 mg/kg. When the BBB is opened in most of one hemisphere by 6,000 rads, the rats are clinically normal and have a normal EEG. When the irradiated rats are challenged with 0.5 mg/kg KA, intense, highly lateralized epileptiform bursts result; these bursts last 1-10 s and recur for 90 mins. This phenomenon is repeatable for the 1 week that the BBB is open. The results are identical when the BBB is opened with a pin lesion. Because endogenous glutamate agonists are common, these data suggest a possible pathophysiologic mechanism for human epilepsy.
AB - Systemic kainic acid (KA) at 1 mg/kg crosses the normal blood-brain barrier (BBB) of rats to produce scattered sharp waves for ~10 min on the EEG, but is without observable effect, producing no EEG or behavioral changes, at 0.5 mg/kg. When the BBB is opened in most of one hemisphere by 6,000 rads, the rats are clinically normal and have a normal EEG. When the irradiated rats are challenged with 0.5 mg/kg KA, intense, highly lateralized epileptiform bursts result; these bursts last 1-10 s and recur for 90 mins. This phenomenon is repeatable for the 1 week that the BBB is open. The results are identical when the BBB is opened with a pin lesion. Because endogenous glutamate agonists are common, these data suggest a possible pathophysiologic mechanism for human epilepsy.
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M3 - Article
VL - 25
SP - 574
EP - 577
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 5
ER -