The biologic effects of bacterial endotoxin: A short review

R. Culbertson, Bennie Osburn

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


This short reveiw considers some of the more widely accepted biological actions of bacterial endotoxin. Early sections concern endotoxin chemical composition, assay techniques, and species variation in toxigenicity. Individual specific actions and classical endotoxin-induced phenomena are presented under headings of pyrogenic effect, hemodynamic effects, disseminated intravascular coagulation, complement system effects, induction of the generalized Shwartzman reaction, effects upon cellular constituents of blood, metabolic and endocrinologic effects, immunologic effects, nervous system effects, hepatic effects, and abortifacient action. The relationship of these effects to clinical manifestations is discussed where warranted.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalVeterinary Science Communications
Issue number1
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • veterinary(all)


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