The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A Randomized, Placebo controlled clinical study

Mei Yu, Zhi Jun Sun, Lian Tao Li, Hong You Ge, Chang Qin Song, Aijun Wang

Research output: Contribution to journalArticle

7 Scopus citations


Objectives: This study aimed to investigate the safety and therapeutic efficacy of herbal drug, Di Huang Yin Zi (DHYZ), in patients affected by ischemic stroke. Methods: In this double blind, placebo-controlled study, a total of 100 patients with recent (less than 30 days) ischemic stroke were randomized to receive DHYZ or placebo for 12 weeks. Both groups also received rehabilitation therapy during the study period. As there were 13 dropouts, a total of 45 patients on DHYZ and 42 on placebo were available for analysis. The Fugl-Meyer Assessment (FMA) and Barthel index (BI) were assessed before treatment and at 4-week intervals. Results: We observed that the FMA score and BI were increased, in both groups at week 4, 8 and 12 compared with the baseline. Furthermore, significantly better FMA score was observed in patients treated with DHYZ at week 8 and 12 (both P2=4.09, P

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalComplementary Therapies in Medicine
Issue number4
StatePublished - Aug 1 2015



  • Chinese medicine
  • Complementary and alternative medicine
  • DHYZ
  • Ischemic stroke

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Advanced and Specialized Nursing
  • Complementary and Manual Therapy

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