The beneficial effects α-cyclodextrin on blood lipids and weight loss in healthy humans

Kevin B. Comerford, Joseph D. Artiss, K. L Catherine Jen, Siddika E Karakas

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. It has previously been reported that early intervention with Mirafit fbcx, a trademarked name for α-CD, has beneficial effects on weight management in obese individuals with type 2 diabetes, and that it preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice. The current investigation involves overweight but not obese nondiabetic individuals and was intended to confirm the effects of α-CD on both weight management and improving blood lipid levels. Forty-one healthy adults (age: 41.4 13.6 years) participated in this 2-month, double-blinded, crossover study. In 28 compliant participants (8 males and 20 females), when the active phase was compared to the control phase, there were significant decreases in body weight (0.4 0.2kg, P 0.05), serum total cholesterol (mean s.e.m., 0.295 0.10mmol/l, 5.3%, P 0.02) and low-density lipoprotein (LDL) cholesterol (0.23 0.11mmol/l, 6.7%, P 0.05). Apolipoprotein B (Apo B) (0.0404 0.02g/l, 5.6%, P = 0.06) and insulin levels also decreased by 9.5% (0.16 0.08pmol/l, P = 0.06) while blood glucose and leptin levels did not change. These results suggest that α-CD exerts its beneficial health effects on body weight and blood lipid profile in healthy nonobese individuals, as previously reported in obese individuals with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1200-1204
Number of pages5
JournalObesity
Volume19
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Cyclodextrins
Weight Loss
Lipids
Type 2 Diabetes Mellitus
Body Weight
Weights and Measures
LDL Receptors
Apolipoproteins B
Leptin
Knockout Mice
LDL Cholesterol
Cross-Over Studies
Zea mays
Names
Blood Glucose
Fats
Cholesterol
Insulin
Health
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

The beneficial effects α-cyclodextrin on blood lipids and weight loss in healthy humans. / Comerford, Kevin B.; Artiss, Joseph D.; Jen, K. L Catherine; Karakas, Siddika E.

In: Obesity, Vol. 19, No. 6, 06.2011, p. 1200-1204.

Research output: Contribution to journalArticle

Comerford, Kevin B. ; Artiss, Joseph D. ; Jen, K. L Catherine ; Karakas, Siddika E. / The beneficial effects α-cyclodextrin on blood lipids and weight loss in healthy humans. In: Obesity. 2011 ; Vol. 19, No. 6. pp. 1200-1204.
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