The Bat as a New Model of Cortical Development

Veronica Martinez-Cerdeno, Jasmin Camacho, Jeanelle Ariza, Hailee Rogers, Kayla Horton-Sparks, Anna Kreutz, Richard Behringer, John J. Rasweiler, Stephen C Noctor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The organization of the mammalian cerebral cortex shares fundamental features across species. However, while the radial thickness of grey matter varies within one order of magnitude, the tangential spread of the cortical sheet varies by orders of magnitude across species. A broader sample of model species may provide additional clues for understanding mechanisms that drive cortical expansion. Here, we introduce the bat Carollia perspicillata as a new model species. The brain of C. perspicillata is similar in size to that of mouse but has a cortical neurogenic period at least 5 times longer than mouse, and nearly as long as that of the rhesus macaque, whose brain is 100 times larger. We describe the development of laminar and regional structures, neural precursor cell identity and distribution, immune cell distribution, and a novel population of Tbr2+ cells in the caudal ganglionic eminence of the developing neocortex of C. perspicillata. Our data indicate that unique mechanisms guide bat cortical development, particularly concerning cell cycle length. The bat model provides new perspective on the evolution of developmental programs that regulate neurogenesis in mammalian cerebral cortex, and offers insight into mechanisms that contribute to tangential expansion and gyri formation in the cerebral cortex.

Original languageEnglish (US)
Pages (from-to)3880-3893
Number of pages14
JournalCerebral cortex (New York, N.Y. : 1991)
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2018

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Cerebral Cortex
Neocortex
Neurogenesis
Brain
Macaca mulatta
Cell Cycle
Population
Gray Matter

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The Bat as a New Model of Cortical Development. / Martinez-Cerdeno, Veronica; Camacho, Jasmin; Ariza, Jeanelle; Rogers, Hailee; Horton-Sparks, Kayla; Kreutz, Anna; Behringer, Richard; Rasweiler, John J.; Noctor, Stephen C.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 28, No. 11, 01.11.2018, p. 3880-3893.

Research output: Contribution to journalArticle

Martinez-Cerdeno, V, Camacho, J, Ariza, J, Rogers, H, Horton-Sparks, K, Kreutz, A, Behringer, R, Rasweiler, JJ & Noctor, SC 2018, 'The Bat as a New Model of Cortical Development', Cerebral cortex (New York, N.Y. : 1991), vol. 28, no. 11, pp. 3880-3893. https://doi.org/10.1093/cercor/bhx251
Martinez-Cerdeno V, Camacho J, Ariza J, Rogers H, Horton-Sparks K, Kreutz A et al. The Bat as a New Model of Cortical Development. Cerebral cortex (New York, N.Y. : 1991). 2018 Nov 1;28(11):3880-3893. https://doi.org/10.1093/cercor/bhx251
Martinez-Cerdeno, Veronica ; Camacho, Jasmin ; Ariza, Jeanelle ; Rogers, Hailee ; Horton-Sparks, Kayla ; Kreutz, Anna ; Behringer, Richard ; Rasweiler, John J. ; Noctor, Stephen C. / The Bat as a New Model of Cortical Development. In: Cerebral cortex (New York, N.Y. : 1991). 2018 ; Vol. 28, No. 11. pp. 3880-3893.
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