The basic defect in cystic fibrosis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Recent evidence strongly suggests that the cystic fibrosis gene product (CFTR) is a Cl- channel. Its properties, however, differ from those of a 30-50 pS outwardly rectifying channel previously implicated as defective in cystic fibrosis. It is still uncertain whether the pleiotropic effects of the CF defect, such as increased airway Na+ absorption and mucus sulfation, are secondary to reduced Cl- conductance, or reflect additional functions of CFTR.

Original languageEnglish (US)
Pages (from-to)474-477
Number of pages4
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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