The B Cell Response to Transplantation Antigens

Roger Sciammas, Anita S. Chong, Robert B. Colvin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

Original languageEnglish (US)
Title of host publicationImmunotherapy in Transplantation: Principles and Practice
PublisherWiley-Blackwell
Pages38-53
Number of pages16
ISBN (Print)9781405182713
DOIs
StatePublished - Apr 19 2012
Externally publishedYes

Fingerprint

Histocompatibility Antigens
B-Lymphocytes
Transplantation
Allografts
Immunosuppression
Cell Biology
T-Lymphocytes
Transplants
Antibodies
Incidence

Keywords

  • Antibody
  • B cell
  • Complement
  • Plasma cell
  • Rejection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sciammas, R., Chong, A. S., & Colvin, R. B. (2012). The B Cell Response to Transplantation Antigens. In Immunotherapy in Transplantation: Principles and Practice (pp. 38-53). Wiley-Blackwell. https://doi.org/10.1002/9781444355628.ch4

The B Cell Response to Transplantation Antigens. / Sciammas, Roger; Chong, Anita S.; Colvin, Robert B.

Immunotherapy in Transplantation: Principles and Practice. Wiley-Blackwell, 2012. p. 38-53.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sciammas, R, Chong, AS & Colvin, RB 2012, The B Cell Response to Transplantation Antigens. in Immunotherapy in Transplantation: Principles and Practice. Wiley-Blackwell, pp. 38-53. https://doi.org/10.1002/9781444355628.ch4
Sciammas R, Chong AS, Colvin RB. The B Cell Response to Transplantation Antigens. In Immunotherapy in Transplantation: Principles and Practice. Wiley-Blackwell. 2012. p. 38-53 https://doi.org/10.1002/9781444355628.ch4
Sciammas, Roger ; Chong, Anita S. ; Colvin, Robert B. / The B Cell Response to Transplantation Antigens. Immunotherapy in Transplantation: Principles and Practice. Wiley-Blackwell, 2012. pp. 38-53
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