The B Cell Response to Transplantation Antigens

Roger Sciammas, Anita S. Chong, Robert B. Colvin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.

Original languageEnglish (US)
Title of host publicationImmunotherapy in Transplantation: Principles and Practice
PublisherWiley-Blackwell
Pages38-53
Number of pages16
ISBN (Print)9781405182713
DOIs
StatePublished - Apr 19 2012
Externally publishedYes

Keywords

  • Antibody
  • B cell
  • Complement
  • Plasma cell
  • Rejection

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sciammas, R., Chong, A. S., & Colvin, R. B. (2012). The B Cell Response to Transplantation Antigens. In Immunotherapy in Transplantation: Principles and Practice (pp. 38-53). Wiley-Blackwell. https://doi.org/10.1002/9781444355628.ch4