The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations

P. Boucher, A. Koning, M. L. Privalsky

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The protein product of the v-erbA oncogene of avian erythroblastosis virus was analyzed by use of site-specific antisera. The v-erbA protein was found to exist in distinct nuclear and cytoplasmic forms. Both nuclear and cytoplasmic species of the v-erbA protein were capable of binding to DNA, a property predicted based on the structural relatedness the v-erbA polypeptide shares with the thyroid and steroid hormone receptors. A mutation within the v-erbA coding region which inhibited DNA binding and nuclear localization also inhibited the ability of the v-erbA protein to potentiate erythroid transformation, consistent with a model of the v-erbA protein as a transcriptional regulator.

Original languageEnglish (US)
Pages (from-to)534-544
Number of pages11
JournalJournal of Virology
Volume62
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology

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