The autoimmune side of heart and lung diseases

Nancy Agmon-Levin, Carlo Selmi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The elevated cardiovascular morbidity in rheumatoid arthritis, systemic lupus erythematosus, and the antiphospholipid syndrome is well known, as well as the pulmonary involvement observed in these conditions and to a major extent in systemic sclerosis. These manifestations constitute a major challenge for clinicians involved in patient management. Moreover, several issues regarding the link between autoimmune rheumatic diseases and cardio pulmonary morbidity remain largely enigmatic. The mechanistic role of certain autoantibodies frequently observed in association with heart and lung diseases or the pathogenetic link between chronic inflammation and the pathways leading to atherosclerosis or pulmonary vascular changes are yet to be elucidated. As such, these questions as well as treatment strategies are of common interest to rheumatologists, immunologist, pulmonologists, and cardiologists and thus call for an interdisciplinary approach. This paradigm has been well established for rare conditions such as the Churg-Strauss syndrome. Nowadays, it seems that this approach should be expanded to encompass more common conditions such as coronary heart disease, pulmonary arterial hypertension or dilated cardiomyopathy. The present issue of Clinical Reviews in Allergy and Immunology addresses the new knowledge and concepts of autoimmune-related cardiopulmonary diseases. The issue derives from the 2010 International Autoimmunity Meeting held in Ljubljana, Slovenia and is thus timely and dedicated to the latest developments in this new multidisciplinary field.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalClinical Reviews in Allergy and Immunology
Volume44
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Lung Diseases
Heart Diseases
Lung
Churg-Strauss Syndrome
Morbidity
Slovenia
Antiphospholipid Syndrome
Systemic Scleroderma
Dilated Cardiomyopathy
Allergy and Immunology
Rheumatic Diseases
Autoimmunity
Pulmonary Hypertension
Systemic Lupus Erythematosus
Autoantibodies
Autoimmune Diseases
Coronary Disease
Blood Vessels
Rheumatoid Arthritis
Atherosclerosis

Keywords

  • Autoantibdoies
  • Autoimmune
  • Cardiovascular
  • Cytokines
  • Heart
  • Lung
  • Smoke

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

The autoimmune side of heart and lung diseases. / Agmon-Levin, Nancy; Selmi, Carlo.

In: Clinical Reviews in Allergy and Immunology, Vol. 44, No. 1, 02.2013, p. 1-5.

Research output: Contribution to journalArticle

Agmon-Levin, Nancy ; Selmi, Carlo. / The autoimmune side of heart and lung diseases. In: Clinical Reviews in Allergy and Immunology. 2013 ; Vol. 44, No. 1. pp. 1-5.
@article{d313fbd097de487e865d1739944a3903,
title = "The autoimmune side of heart and lung diseases",
abstract = "The elevated cardiovascular morbidity in rheumatoid arthritis, systemic lupus erythematosus, and the antiphospholipid syndrome is well known, as well as the pulmonary involvement observed in these conditions and to a major extent in systemic sclerosis. These manifestations constitute a major challenge for clinicians involved in patient management. Moreover, several issues regarding the link between autoimmune rheumatic diseases and cardio pulmonary morbidity remain largely enigmatic. The mechanistic role of certain autoantibodies frequently observed in association with heart and lung diseases or the pathogenetic link between chronic inflammation and the pathways leading to atherosclerosis or pulmonary vascular changes are yet to be elucidated. As such, these questions as well as treatment strategies are of common interest to rheumatologists, immunologist, pulmonologists, and cardiologists and thus call for an interdisciplinary approach. This paradigm has been well established for rare conditions such as the Churg-Strauss syndrome. Nowadays, it seems that this approach should be expanded to encompass more common conditions such as coronary heart disease, pulmonary arterial hypertension or dilated cardiomyopathy. The present issue of Clinical Reviews in Allergy and Immunology addresses the new knowledge and concepts of autoimmune-related cardiopulmonary diseases. The issue derives from the 2010 International Autoimmunity Meeting held in Ljubljana, Slovenia and is thus timely and dedicated to the latest developments in this new multidisciplinary field.",
keywords = "Autoantibdoies, Autoimmune, Cardiovascular, Cytokines, Heart, Lung, Smoke",
author = "Nancy Agmon-Levin and Carlo Selmi",
year = "2013",
month = "2",
doi = "10.1007/s12016-012-8335-x",
language = "English (US)",
volume = "44",
pages = "1--5",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - The autoimmune side of heart and lung diseases

AU - Agmon-Levin, Nancy

AU - Selmi, Carlo

PY - 2013/2

Y1 - 2013/2

N2 - The elevated cardiovascular morbidity in rheumatoid arthritis, systemic lupus erythematosus, and the antiphospholipid syndrome is well known, as well as the pulmonary involvement observed in these conditions and to a major extent in systemic sclerosis. These manifestations constitute a major challenge for clinicians involved in patient management. Moreover, several issues regarding the link between autoimmune rheumatic diseases and cardio pulmonary morbidity remain largely enigmatic. The mechanistic role of certain autoantibodies frequently observed in association with heart and lung diseases or the pathogenetic link between chronic inflammation and the pathways leading to atherosclerosis or pulmonary vascular changes are yet to be elucidated. As such, these questions as well as treatment strategies are of common interest to rheumatologists, immunologist, pulmonologists, and cardiologists and thus call for an interdisciplinary approach. This paradigm has been well established for rare conditions such as the Churg-Strauss syndrome. Nowadays, it seems that this approach should be expanded to encompass more common conditions such as coronary heart disease, pulmonary arterial hypertension or dilated cardiomyopathy. The present issue of Clinical Reviews in Allergy and Immunology addresses the new knowledge and concepts of autoimmune-related cardiopulmonary diseases. The issue derives from the 2010 International Autoimmunity Meeting held in Ljubljana, Slovenia and is thus timely and dedicated to the latest developments in this new multidisciplinary field.

AB - The elevated cardiovascular morbidity in rheumatoid arthritis, systemic lupus erythematosus, and the antiphospholipid syndrome is well known, as well as the pulmonary involvement observed in these conditions and to a major extent in systemic sclerosis. These manifestations constitute a major challenge for clinicians involved in patient management. Moreover, several issues regarding the link between autoimmune rheumatic diseases and cardio pulmonary morbidity remain largely enigmatic. The mechanistic role of certain autoantibodies frequently observed in association with heart and lung diseases or the pathogenetic link between chronic inflammation and the pathways leading to atherosclerosis or pulmonary vascular changes are yet to be elucidated. As such, these questions as well as treatment strategies are of common interest to rheumatologists, immunologist, pulmonologists, and cardiologists and thus call for an interdisciplinary approach. This paradigm has been well established for rare conditions such as the Churg-Strauss syndrome. Nowadays, it seems that this approach should be expanded to encompass more common conditions such as coronary heart disease, pulmonary arterial hypertension or dilated cardiomyopathy. The present issue of Clinical Reviews in Allergy and Immunology addresses the new knowledge and concepts of autoimmune-related cardiopulmonary diseases. The issue derives from the 2010 International Autoimmunity Meeting held in Ljubljana, Slovenia and is thus timely and dedicated to the latest developments in this new multidisciplinary field.

KW - Autoantibdoies

KW - Autoimmune

KW - Cardiovascular

KW - Cytokines

KW - Heart

KW - Lung

KW - Smoke

UR - http://www.scopus.com/inward/record.url?scp=84872687592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872687592&partnerID=8YFLogxK

U2 - 10.1007/s12016-012-8335-x

DO - 10.1007/s12016-012-8335-x

M3 - Article

C2 - 23054981

AN - SCOPUS:84872687592

VL - 44

SP - 1

EP - 5

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 1

ER -